Corticotropin releasing factor receptor 1-deficient mice

Details Corticotropin releasing factor receptor 1-deficient mice Corticotropin releasing factor receptor 1-deficient mice

1999-03-30

2000-11-14

Campell, Bruce R.

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

Transgenic nonhuman animal

A01K 62027

Patent

active

061472751

ABSTRACT:
Signaling pathways dependent on members of the corticotropin releasing factor (CRF) gene family exert pleiotropic effects within both the brain and peripheral tissues. Two biochemically and pharmacologically distinct corticotropin releasing factor receptor subtypes (corticotropin releasing factor receptor-1 and corticotropin releasing factor receptor-2) have been described. To study the developmental and physiological role of the specific receptor subtypes, a strain of mice null for the corticotropin releasing factor receptor-1 gene has been generated. This genetically engineered strain of mice suggest that corticotropin releasing factor receptor-1 is obligatory both in development and function of the hypothalamic-pituitary-adrenal axis and in mediating behavioral changes associated with anxiety and locomotor activity rhythms.

REFERENCES:
Theiler (in: The House Mouse, Atlas of Embryonic Development, Springer-Verlag, publishers, see pp. 148 and 149, 1989.

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