Multicellular living organisms and unmodified parts thereof and – Nonhuman animal – Transgenic nonhuman animal
Patent
1993-05-28
2000-02-08
Crouch, Deborah
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
Transgenic nonhuman animal
800 9, 800 3, 800 25, 435455, 536 241, 536 231, 536 234, 536 2351, 536 235, C12N 500, C12N 1500, C12N 1509, C12N 1563
Patent
active
060230118
ABSTRACT:
In accordance with the present invention, there are provided CRF overproducing transgenic mice which exhibit endocrine abnormalities involving the hypothalamic-pituitary-adrenal axis, such as elevated plasma levels of ACTH and glucocorticoids. The transgenic mice of the present invention represent a genetic model of CRF overproduction, providing a valuable tool for investigating the long term effects of CRF excess and dysregulation in the central nervous system.
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Cameron et al., "Tissue Distribution of CRF Over-Expression in Transgenic Mice," Society for Neuroscience Abstracts, vol. 17., No. 434.4 (1991).
Stenzel-Poore and Vale, "Corticotropin-Releasing Factor (CRF) Transgenics: A Mouse Model of Chronic CRF and Glucocorticoid Overproduction which Mimics Cushing's Syndrome," Journal of Cellular Biochem. 15A:203 (1991).
Stenzel-Poore et al., "Development of Cushing's Syndrome in Corticotropin-Releasing Factor Transgenic Mice," Endocrinology 130:3378-3386 (1992).
Stenzel-Poore Mary P.
Vale, Jr. Wylie W.
Crouch Deborah
Kleinsmith David F.
Martin Jill D.
Reiter Stephen E.
The Salk Insitute for Biological Studies
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