Corticotropin-releasing factor overproducing transgenic mice

Multicellular living organisms and unmodified parts thereof and – Nonhuman animal – Transgenic nonhuman animal

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800 9, 800 3, 800 25, 435455, 536 241, 536 231, 536 234, 536 2351, 536 235, C12N 500, C12N 1500, C12N 1509, C12N 1563

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active

060230118

ABSTRACT:
In accordance with the present invention, there are provided CRF overproducing transgenic mice which exhibit endocrine abnormalities involving the hypothalamic-pituitary-adrenal axis, such as elevated plasma levels of ACTH and glucocorticoids. The transgenic mice of the present invention represent a genetic model of CRF overproduction, providing a valuable tool for investigating the long term effects of CRF excess and dysregulation in the central nervous system.

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Schmid et al. 1991. Development 113:857-865.
Cameron et al., "Tissue Distribution of CRF Over-Expression in Transgenic Mice," Society for Neuroscience Abstracts, vol. 17., No. 434.4 (1991).
Stenzel-Poore and Vale, "Corticotropin-Releasing Factor (CRF) Transgenics: A Mouse Model of Chronic CRF and Glucocorticoid Overproduction which Mimics Cushing's Syndrome," Journal of Cellular Biochem. 15A:203 (1991).
Stenzel-Poore et al., "Development of Cushing's Syndrome in Corticotropin-Releasing Factor Transgenic Mice," Endocrinology 130:3378-3386 (1992).

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