Corticotropin-releasing factor overproducing transgenic mice

Details Corticotropin-releasing factor overproducing transgenic mice Corticotropin-releasing factor overproducing transgenic mice

1999-06-04

2000-12-26

Chambers, Jasemine

Multicellular living organisms and unmodified parts thereof and

Method of using a transgenic nonhuman animal in an in vivo...

800 18, 800 9, 435455, 4353201, C12N 1509, C12N 1563, C12N 1500

Patent

active

061662879

ABSTRACT:
In accordance with the present invention, there are provided CRF overproducing transgenic mice which exhibit endocrine abnormalities involving the hypothalamic-pituitary-adrenal axis, such as elevated plasma levels of ACTH and glucocorticoids. The transgenic mice of the present invention represent a genetic model of CRF overproduction, providing a valuable tool for investigating the long term effects of CRF excess and dysregulation in the central nervous system.

REFERENCES:
patent: 5219855 (1993-06-01), Saito et al.
patent: 5221778 (1993-06-01), Byrne et al.
patent: 6023011 (2000-02-01), Vale, Jr. et al.
Thompson et al. 1987 Annals of The New York Academy of Sciences 512:1-11.
Palmiter et al. 1983. Science 222:809-814.
Schmid et al. 1991. Development 113:857-865.
Hotta et al. 1991. Life Sciences 48:1483-1491.
Low et al. 1986. J. Biol. Chem. 261(34):16260-16263.
Sutton et al. 1982. Nature 297:331-333.
Cameron et al., "Tissue Distribution of CRF Over-Expression in Transgenic Mice," Society for Neuroscience Abstracts, vol. 17., No. 434.4 (1991).
Stenzel-Poore and Vale, "Corticotropin-Releasing Factor (CRF) Transgenics: A Mouse Model of Chronic CRF and Glucocorticoid Overproduction which Mimics Cushing's Syndrome," Journal of Cellular Biochem. 15A:203 (1991).
Stenzel-Poore et al., "Development of Cushing's Syndrome in Corticotropin-Releasing Factor Transgenic Mice," Endocrinology 130:3378-3386 (1992).

Affiliated with

Also associated with

Rating

Corticotropin-releasing factor overproducing transgenic mice does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Corticotropin-releasing factor overproducing transgenic mice, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Corticotropin-releasing factor overproducing transgenic mice will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-996976