Organic compounds -- part of the class 532-570 series – Organic compounds – Cyclopentanohydrophenanthrene ring system containing
Patent
1994-08-25
1997-03-04
Wu, Shean C.
Organic compounds -- part of the class 532-570 series
Organic compounds
Cyclopentanohydrophenanthrene ring system containing
540107, 540108, 540111, 540112, 540113, 540114, 552588, 552595, C07J 500, C07J 4300, A61K 3156
Patent
active
056080930
ABSTRACT:
Corticoid 17-alkyl carbonate 21-carboxylic and carbonic esters of the formula I ##STR1## are described in which A is CHOH and CHCl, CH.sub.2, C.dbd.O or 9(11) double bond; Y is H, F or Cl; Z is H, F or CH.sub.3 ; R(1) is aryl or hetaryl; n and m are zero or 1; R(2) is alkyl or --(CH.sub.2).sub.2 --OCH.sub.3 ; R(3) is H or methyl. They are obtained by reacting a compound of the formula II, ##STR2## in which R(5) is OH, with an activated carboxylic acid of the formula III,
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Alpermann Hans-Georg
Bohn Manfred
D urckheimer Walter
Stache Ulrich
Hoechst Aktiengesellschaft
Wu Shean C.
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