Corticoid derivatives and pharmaceutical and cosmetic compositio

Details Corticoid derivatives and pharmaceutical and cosmetic compositio Corticoid derivatives and pharmaceutical and cosmetic compositio

1996-07-29

1998-07-07

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

540 5, 514171, C07F 909, A61K 31665

Patent

active

057769222

ABSTRACT:
1. A corticoid derivative of the general formula ##STR1## wherein R represents hydrogen, hydroxy, methyl or methylene; inclusive of the acylation product thereof where the 17-position of the steroid skeleton is hydroxy and the ketone form thereof where R is hydroxy, or a physiologically acceptable salt thereof.
Since the corticosteroid derivative of this invention is readily soluble in water and has antiallergic, antiinflammatory and antioxidant activities, it can be used with advantage in the prevention and therapy of various allergic diseases, inflammatory diseases, cataract and various ischemic organ diseases.

REFERENCES:
patent: 4939128 (1990-07-01), Kato et al.
Patent Abstracts of Japan; vol. 016, No. 338 (22 Jul. 1992); JP-A 4 099 772 Kanebo Ltd.; 31 Mar. 1992.

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