Correction of the effect of spatial gradient field...

Electricity: measuring and testing – Particle precession resonance – Using a nuclear resonance spectrometer system

Reexamination Certificate

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C324S309000

Reexamination Certificate

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06969991

ABSTRACT:
A general mathematical framework is formulated to characterize the contribution of gradient non-uniformities to diffusion tensor imaging in MRI. Based on a model expansion, the actual gradient field is approximated and employed, after elimination of geometric distortions, for predicting and correcting the errors in diffusion encoding. Prior to corrections, experiments clearly reveal marked deviations of the calculated diffusivity for fields of view generally used in diffusion experiments. These deviations are most significant with greater distance from the magnet's isocenter. For a FOV of 25 cm the resultant errors in absolute diffusivity can range from approximately −10 to +20 percent. Within the same field of view, the diffusion-encoding direction and the orientation of the calculated eigenvectors can be significantly altered if the perturbations by the gradient non-uniformities are not considered. With the proposed correction scheme most of the errors introduced by gradient non-uniformities can be removed.

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Bammer et al., “Assessment of Spatial Gradient Field Distortion in Duffusion Weighted Imaging,” ISMRM Abstract, Dec. 12, 2001.
Bammer et al., “Assessment and Correction of Spatial Gradient Field Distortions in Diffusion-Weighted Imaging,” ISMRM poster, May 10, 2002.

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