Coronary therapeutic agent in the form of soft gelatin capsules

Details Coronary therapeutic agent in the form of soft gelatin capsules Coronary therapeutic agent in the form of soft gelatin capsules

1986-01-06

1987-08-25

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424 80, 424456, 514356, 514962, A61K 948, A61K 966

Patent

active

046892338

ABSTRACT:
The present invention relates to a coronary therapeutic agent in the form of soft gelatin capsules, which contain the active substance nifedipine in an organic solvent. In the prior art, there where problems regarding the capsule size and with respect to the low nifedipine active substance concentration. These problems are obviated by the invention, in that nifedipine with PVP, optionally as a coprecipitate and without glycerin, is dissolved in THFP and consequently permits a capsule weight of in all only e.g. 162 mg.

REFERENCES:
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Dvorsky et al, CA 104:136082b, (1986) of EPO 143857, Jun. 12, 1985.
Nippon Chemiphar, CA 104:10590x, (1986) of JP 60,105,611, Jun. 11, 1985.
Nippon Chemiphar, CA 99:128364h, (1983) of JP 58,105,913, Jun. 24, 1983.

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