Coronary sinus lead having expandable matrix anchor

Surgery: light – thermal – and electrical application – Light – thermal – and electrical application – Electrical energy applicator

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A61N 105

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active

059515970

ABSTRACT:
An intravenous lead for use with a cardiac device for implantation in the coronary venous system of the heart includes a lead body that is adapted to be routed through the vascular system into the coronary sinus with the distal end portion of the lead placed in the great cardiac vein or branch vein. The lead body includes a fixation member disposed just proximal of its tip. The fixation member comprises a radially expandable polymeric matrix that incorporates an osmotic agent so that when placed in a aqueous medium it will swell. Thus, when placed in a cardiac vein, the swelling of the fixation member will anchor the lead against longitudinal displacement due to body motion, blood flow and the beating action of the heart.

REFERENCES:
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"Effect of Water-Soluble Additves on Drug Release From Silicone Rubber Matrices. III. A Study of Release Mechanism by Differential Scanning Calorimetry"; V. Carelli et al. International Journal of Pharmaceutics, 30 (1986) 9-15.
"Effect of Water-Soluble Additives on Drug Release from Silicone Rubber Matrices. II. Sustained Release of Prednisolone From Non-Swelling Devices"; G. Di Colo, et al.; International Journal of Pharmaceutics, 30 (1986) 1-7.
"The Relationship Between Drug Release Rate, Particle Size and Swelling Of Silicone Matrices"; Gershon Golomb et al; Journal Of Controlled Release, 12 (1990) 121-132.
"Osmotic Effects in Water Absorption By Polymers"; R.F. Fedors, Polymer, 1980, vol. 21, Feb. 207-212.

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