Corona ion generating method and apparatus for the...

Chemistry: molecular biology and microbiology – Process of mutation – cell fusion – or genetic modification – Fusion of cells

Reexamination Certificate

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C435S461000, C435S470000, C435S285200

Reexamination Certificate

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06929949

ABSTRACT:
The present invention provides a method and apparatus adapted to facilitate the entry of a preselected molecule into the intracellular space of a cellular sample through the use of ions generated by a corona charge source. With the present method and apparatus, molecules are manipulated within cells and in the extracellular space surrounding the cells. Manipulation enhances the permeability of cell barriers to allow the subsequent introduction of molecules of interest into the interior of a cell.

REFERENCES:
patent: 4413897 (1983-11-01), Kohyama
patent: 4656356 (1987-04-01), Yoda et al.
patent: 5869326 (1999-02-01), Hofmann
patent: 5983131 (1999-11-01), Weaver et al.

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