Chemistry: molecular biology and microbiology – Differentiated tissue or organ other than blood – per se – or... – Including perfusion; composition therefor
Patent
1984-01-10
1987-09-22
Rosen, Sam
Chemistry: molecular biology and microbiology
Differentiated tissue or organ other than blood, per se, or...
Including perfusion; composition therefor
4352403, 4352402, A01N 102
Patent
active
046955364
ABSTRACT:
A universal tissue preservation system including a storage container and a preservation media for corneal and other tissue storage. The universal corneal preservation system provides for closed system storage (media not changed) at 4.degree. centigrade under refrigeration for 1-14 days or 34.degree. centigrade storage in an incubator for at least 35 days (five weeks). The storage system provides for a quarantine technique insuring sterility, and a special media for maintaining cell viability and corneal deturgescence, (normal thickness). The corneal storage container provides for endothelial cell photography and media sampling. The preservation media can also be utilized in an open batch technique (media changed at regular intervals) for storage of corneas over one year. In addition, the preservation media can be used as an intraocular irrigation fluid during surgery.
REFERENCES:
patent: 4282326 (1981-08-01), Moldenhauer
patent: 4443546 (1984-04-01), Stemerman et al.
Gibco Catalog (1978-1979).
Kaufman et al.-Am. J. of Ophthalmology, Jul. 1984, pp. 112-114.
Recent Advances in Kertoplasty with Special Reference to the Advantage of Liquid Preservation by Takashi and Reizo Marabe-Folia Ophthalmological Japonica 19(12): 1310-1318, (1968).
Organ Preservation for Transplantation by Karow and Pegg, 1981, pp. 427-441.
Organ Culture Corneal Storage at Ambient Room Temperature, Lindstrom et al., Archives of Ophthalmology, vol. 95, pp. 869-878, May, 1977.
Chondroitin Sulfate in a New Cornea Preservation Medium, Kaufman et al., American Journal of Opthalmology, Jul. 1984, pp. 112-114.
Doughman Donald J.
Lindstrom Richard L.
Skelnik Debra
Jaeger Hugh D.
Rosen Sam
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