Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase
Reexamination Certificate
2002-06-25
2004-10-19
Achutamurthy, Ponnathapura (Department: 1652)
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Hydrolase
C435S023000, C435S069100, C435S252300, C435S320100, C536S023200
Reexamination Certificate
active
06806075
ABSTRACT:
BACKGROUND OF THE INVENTION
Serine proteases participate in a variety of developmental and physiological processes (Stroud R.
Sci. Am
. 231:74-88, 1974: Neurath H.
Science
224:350-357, 1984). For instance, serine proteases are involved in cell signaling, cell differentiation, and the conversion of pro-hormones to biologically-active forms. See, e.g., Hong and Hashimoto.
Cell
. 82:785-794, 1995: Inagami.
J. Biol. Chem
., 264:3043-3046, 1989.
DESCRIPTION OF THE INVENTION
The present invention relates to nucleic acids, polypeptides and fragments thereof, of a novel gene, e.g., a serine protease especially a mammalian serine protease, such as human and mouse corin which contains one or more frizzled, LDLR, scavenger receptor cysteine-rich repeats, and serine protease catalytic domains. The invention further relates to methods of using such nucleic acids and polypeptides in therapeutics, diagnostics, and research. For example, the nucleic acids and polypeptides of corin can be utilized in methods to identify modulators of its activity and in animal models to mimic human disease, and in the diagnosis of pathological conditions.
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Seffernick, J. L. et al., 2001. “Melamine deaminase and atrazine chlorohydrolase: 98 percent identical but functionally different”, Journal of Biochemistry, vol. 183, pp. 2405-2410.*
W. Yan et al., “Corin, a Mosaic Transmembrane Serine Protease Encoded By A Novel cDNA from Human Heart,” Database Medline (Online), U.S. National Library of Medicine (NLM), Bethesda, MD, XP002119684, Abstract & Journal of Biological Chemistry, May 21, 1999, vol. 274 (21) pp. 14926-35.
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Morser John Michael
Wu Qingyu
Yan Wei
Achutamurthy Ponnathapura
Millen White Zelano & Branigan P.C.
Moore William W.
Schering AG
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