Cores for technetium radiopharmaceuticals

Details Cores for technetium radiopharmaceuticals Cores for technetium radiopharmaceuticals

2000-05-11

2001-12-11

Jones, Dameron L. (Department: 1619)

Organic compounds -- part of the class 532-570 series

Organic compounds

Radioactive metal containing

C536S016000, C424S001110, C424S001530

Reexamination Certificate

active

06329513

ABSTRACT:

This invention relates to novel complexes of technetium (Tc), containing the moiety Tc═NR, Tc—N═NY or Tc(—N═NY)
2
, and their use in radiopharmaceuticals for a variety of clinical applications. Methods for the preparation of the technetium complexes are also described.
Radiopharmaceuticals may be used as diagnostic or therapeutic agents by virtue of the physical properties of their constituent radionuclides. Thus, their utility is not based on any pharmacologic action. Most clinically used drugs of this class are diagnostic agents incorporating a gamma-emitting nuclide which, because of physical or metabolic properties of its coordinated ligands, localises in a specific organ after intravenous injection. The resultant images can reflect organ structure or function. These images are obtained by means of a gamma camera that detects the distribution of ionising radiation emitted by the radioactive molecules. The principal isotope currently used in clinical diagnostic nuclear medicine is metastable technetium-99m (
99m
Tc) and which has a half-life of 6 hours.


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