Cores for technetium radiopharmaceuticals

Details Cores for technetium radiopharmaceuticals Cores for technetium radiopharmaceuticals

1994-08-12

1996-12-31

Kight, John

Organic compounds -- part of the class 532-570 series

Organic compounds

Radioactive metal containing

C07F 1300, A61K 5104

Patent

active

055895760

ABSTRACT:
Novel complexes of technetium (.sup.99 Tc or .sup.99m Tc) which contain the moiety Tc.dbd.NR, Tc--N.dbd.NY or Tc(--N.dbd.NY).sub.2, and a ligand which confers biological target-seeking properties on the complex, wherein R represents an aryl group, a substituted or unsubstituted alkyl group, or the grouping .dbd.NR.sup.1 R.sup.2 ; Y represents an aryl group or a substituted or unsubstituted alkyl group; and R.sup.1 and R.sup.2 are hydrogen, aryl groups or substituted or unsubstituted aliphatic or cyclic alkyl groups, and may be both the same or different, provided that both are not hydrogen. The complexes are suitable for use in radiopharmaceuticals for a variety of clinical applications. Methods for the preparation of these technetium complexes are also described.

REFERENCES:
patent: 4431627 (1984-02-01), Eckelman et al.
patent: 4781912 (1988-11-01), Zanelli et al.
D. L. Dubois et al., "Diazenido, dinitrogen, and related complexes", Nouveau Journal de Chimie, vol. 1, No. 6, 479-492, 1978.
Moore et al., Inorganic Chemistry, 6(5), 998-1003 (May 1967).
Chisholm, M. et al., "Comprehensive Coordination Chemistry", vol. 2, 161-189 (1987).
Bright, D. et al., "Inorganic Chemistry", 7(6) 1099-1117 (Jun. 1968).
Bright, D. et al., "Inorganic Chemistry", 8(4) 703-709 (Apr. 1969).
Angelici, R. et al., "Inorganic Chemistry", 6(5) 988-998 (May 1967).
Chatt, J. et al., "Inorganic Chemistry", 21 2383-2391 (1982).
Hsieh, T-C. et al., "Inorganic Chemistry", 26 4079-4089 (1987).
Colton, R. et al., "Aust. J. Chem.", 17 496-497 (1964).
McCleverty, J. et al., "Transition Met. Chem.", 12 4-8 (1987).
Chou, C. et al., "J. Chem. Soc., Chem. Comm.", 1184-1185 (1984).
Johnson, B. et al., "Comprehensive Coordination Chemistry", 101-159 (1988).
Nugent, W. et al., "Coordination Chemistry Reviews", 31, 123-175 (1980).
Goeden, G. et al., "Inorganic Chemistry," 22(1) 157-167 (1983).
Bradley, D. et al., "J. Chem. Soc. Dalton Trans.," 2651-2656 (1983).
Maatta, E. et al., "Inorganic Chemistry," vol. 23, 2560-2561 (1984).

Affiliated with

Also associated with

Rating

Cores for technetium radiopharmaceuticals does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Cores for technetium radiopharmaceuticals, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cores for technetium radiopharmaceuticals will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1142905