Cores for technetium radiopharmaceuticals

Details Cores for technetium radiopharmaceuticals Cores for technetium radiopharmaceuticals

1996-12-24

1999-12-14

Dees, Jose' G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Radioactive metal containing

424 153, 424 111, 534 16, C07F 1300

Patent

active

060019794

ABSTRACT:
A synth .sup.99m Tc complex which contains the moiety Tc.dbd.NR, Tc--N.dbd.NY or Tc(--N.dbd.NY).sub.2 and an organic ligand which confers biological target-seeking properties on the technetium complex, where R is an aryl group, a substituted or unsubstituted alkyl group or the group --NR.sup.1 R.sup.2 ; Y is an aryl group or a substituted or unsubstituted alkyl group; and R.sup.1 and R.sup.2 are H, aryl groups or substituted or unsubstituted aliphatic or cyclic alkyl groups, and are the same or different provided that both are not hydrogen. Radiopharmaceuticals comprising this complex are also described, together with methods for the preparation of the complex.

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