Core substance-containing calcium microparticles and methods for

Details Core substance-containing calcium microparticles and methods for Core substance-containing calcium microparticles and methods for

1999-01-11

2000-12-12

Dodson, Shelley A.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

A61K 914

Patent

active

061595047

ABSTRACT:
It is an object of the invention to provide core substance-containing calcium microparticles and methods for producing them.
As means to solve the above problem, an edible oil, a calcium shell-forming material and water are agitated at a high rate to thereby form an o/w emulsion and, at the same time, allow electrostatic adsorption of calcium microparticles on the surface of oil droplets in the emulsion; the calcium microparticles adsorbed on the oil droplets are solidified to allow formation of calcium shells; the resultant edible-oil-containing calcium shells are separated; the edible oil is replaced with a solvent; the solvent is removed by volatilization to thereby obtain porous, hollow calcium shells; a core substance is introduced into the porous, hollow calcium shells; and, if necessary, the resultant core substance-containing calcium microparticles are coated with a biopolymer.
The present invention has made it possible to select, as a core substance, not only an oily substance or oil-soluble substance but also a water-soluble substance, suspension or microorganism. Furthermore, if the calcium microparticles of the invention are coated with a biopolymer, a function depending on the property of the polymer, e.g. taste or odor-masking property or slow release property, can be conferred.

REFERENCES:
patent: 5648097 (1997-07-01), Nuwayser

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