Core structure of gp41 from the HIV envelope glycoprotein

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage

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435 691, 530324, C12Q 170, C12P 2106, A61K 3800, C07K 500

Patent

active

061500887

ABSTRACT:
Described are the crystal structure of the .alpha.-helical domain of the gp41 component of HIV-1 envelope glycoprotein which represents the core of fusion-active gp41, methods of identifying and designing drugs which inhibit gp41 function and drugs which do so.

REFERENCES:
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Kuntz, Irwin D., "Structure-Based Strategies for Drug Design and Discovery," Science 257:1078-1082 (Aug. 1992).
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Chambers, Philip, et al., "Heptad Repeat Sequences are Located Adjacent to Hydrophobic Regions in Several Types of Virus Fusion Glycoproteins," Journal of General Virology, 71:3075-3080 (1990).
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Delwart, Eric L., et al., "Retroviral Envelope Glycoproteins Contain a `Leucine Zipper`--like Repeat," AIDS Research and Human Retroviruses, (vol. 6(6):703-706 (1990).

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