Core 1 β3-galactosyltransferase specific molecular...

Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of...

Reexamination Certificate

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C435S320100, C435S069100, C435S015000, C435S252300, C435S193000, C536S023100, C536S023200, C536S023500, C530S350000

Reexamination Certificate

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10661049

ABSTRACT:
Core 1 β3-galactosyl transferase specific molecular chaperones (Cosmc-1) and nucleic acids encoding the core 1 β3-galactosyl transferase specific molecular chaperones or proteins having core 1 β3-galactosyl transferase specific molecular chaperone activity are described. The polynucleotides encoding Cosmc-1 can be used to transform or transfect host cells for producing substantially pure forms of active forms of core 1 β3-galactosyl transferase and/or for use in an expression system for post-translational core 1 glycosylation of proteins or peptides produced within the expression system, for example, glycosylation via a β3-linkage, of an N-acetylgalactosamine linked to a serine, threonine or other linking amino acid on peptides or proteins requiring O-, N-, or S-linked glycosylation.

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