Coordination complexes of platinum useful as antiproliferative a

Details Coordination complexes of platinum useful as antiproliferative a Coordination complexes of platinum useful as antiproliferative a

1987-05-26

1989-08-01

Shaver, Paul F.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514492, 556137, A61K 31555, A61K 3128

Patent

active

048533807

ABSTRACT:
Platinum complexes are disclosed in which the platinum cation is coordinated to heterocyclic sulfur compounds as well as monodentate or bidentate amines. The complexes have the formula: ##STR1## wherein L.sub.1 and L.sub.2 are individually ammonia or monodentate amine ligands or L.sub.1 and L.sub.2 together are a bidentate amine ligand, S* is sulfur and R.sub.1 and R.sub.2 taken together with S are thiophene, thiazole, benzothiazole or benzothiophene. These platinum complexes, which have anti-neoplastic activity, are synthesized by reacting sulfonated heterocyclic sulfur compounds with diamines of platinum nitrate.

REFERENCES:
Translation of USSR Inventor's Certificate 914, 557.

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