Cooperative combinations of ligands contained within a matrix

Details Cooperative combinations of ligands contained within a matrix Cooperative combinations of ligands contained within a matrix

1995-06-01

1998-11-03

Ulm, John

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Matrices

424486, 514 2, 514 3, A61K 3804, A61K 3818, A61K 3820, A61K 3828

Patent

active

058305041

ABSTRACT:
The present invention provides compositions and methods for promoting cell migration and tissue regeneration. The composition contains a ligand for the .alpha..sub.v .beta..sub.3 integrin and a ligand for the insulin receptor, the PDGF receptor, the IL-4 receptor, or the IGF receptor, combined in a matrix. The combination of .alpha..sub.v .beta..sub.3 ligand and growth factor produces an unexpected synergistic effect in enhancing wound healing compared with the effect of each component separately. The present invention also provides a method of wound healing and a method of inducing tissue regeneration by applying the compositions of the present invention to the site of the wound.

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