Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1995-04-20
1997-07-08
Russel, Jeffrey E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
424400, 514 12, 514937, A61K 9107, A61K 3800, A61K 3816, A61K 3900
Patent
active
056461097
ABSTRACT:
There is provided a water-in-oil (w/o) microemulsion which readily converts to an oil-in-water (o/w) emulsion by the addition of aqueous fluid to the w/o microemulsion, whereby any water-soluble biologically-active material in the aqueous phase is released for absorption by the body. The w/o microemulsion is particularly useful for storing proteins and the like for long periods of time at room temperature and above until they are ready for use, at which time the addition of aqueous fluid converts the microemulsion to an o/w emulsion and releases the protein.
REFERENCES:
patent: 3083142 (1963-03-01), Howell et al.
patent: 3100178 (1963-08-01), McLean et al.
patent: 3149036 (1964-09-01), Woodhour et al.
patent: 3438782 (1969-04-01), Elenbogen et al.
patent: 3492399 (1970-01-01), Prigal
patent: 3776857 (1973-12-01), Lindner
patent: 3983228 (1976-09-01), Woodhour et al.
patent: 4094971 (1978-06-01), Chedid et al.
patent: 4104403 (1978-08-01), Barker et al.
patent: 4122158 (1978-10-01), Schmitt
patent: 4183918 (1980-01-01), Asher et al.
patent: 4241051 (1980-12-01), Christie et al.
patent: 4395394 (1983-07-01), Wolff, III et al.
patent: 4460692 (1984-07-01), Tellier et al.
patent: 4481188 (1984-11-01), Apontowell et al.
patent: 4650677 (1987-03-01), Roerink
patent: 4690774 (1987-09-01), Vishnupad et al.
patent: 4692433 (1987-09-01), Hostetler et al.
patent: 4711902 (1987-12-01), Serno
patent: 4719239 (1988-01-01), Muller et al.
patent: 4720353 (1988-01-01), Bell
patent: 4731384 (1988-03-01), Dell et al.
patent: 4781914 (1988-11-01), Deckner
patent: 4797273 (1989-01-01), Linn et al.
patent: 4803070 (1989-02-01), Cantrell et al.
patent: 4806350 (1989-02-01), Gerber
patent: 4806352 (1989-02-01), Cantrell
patent: 4914084 (1990-04-01), Ecanow
patent: 4931210 (1990-06-01), Takahashi et al.
patent: 4963367 (1990-10-01), Ecanow
patent: 4980084 (1990-12-01), Vishnupad et al.
patent: 5002771 (1991-03-01), Purkaystha et al.
patent: 5026825 (1991-06-01), Grebow et al.
patent: 5036045 (1991-07-01), Thorner
patent: 5036108 (1991-07-01), Asahi et al.
patent: 5037653 (1991-08-01), Dawson
patent: 5045337 (1991-09-01), El Nokaly et al.
patent: 5064653 (1991-11-01), Session et al.
patent: 5084289 (1992-01-01), Shin et al.
patent: 5110606 (1992-05-01), Geyer et al.
patent: 5206219 (1993-04-01), Desai
patent: 5371109 (1994-12-01), Engstrom et al.
patent: 5444041 (1995-08-01), Owen et al.
Charman, S. et al., "Self-Emulsifying Drug Delivery Systems: Formulaiton and Biopharmaceutic Evaluation of an Investigational Lipophilic Compound", Pharmaceutical Research 1992, 9(1), 87-93.
Engstrom, L, "Aggregation and Structural Changes in the L2-Phase in the System Water/Soybean Oil/Sunflower Oil Monoglycerides", J. Dispersion Science and Technology 1990, 11 (5), 479-489.
Engstrom, S. et al., "Enzyme Stabilization in Composite Cubic Phases", Annals New York Academy of Sciences 1990, 613, 429-30.
Engstroem, S., "Cubic Phases as Drug Delivery Systems", Am. Chem. Soc., Div. Polym. Chem. 1990, 31 (2), 157-158.
Fletcher, P. and Parrott, "The Partitioning of Proteins between Water-in-oil Microemulsions and Conjugate Aqueous Phases", J. Chem. Soc., Faraday Trans. 1, 1988, 84 (4), 1131-1144.
Fiedler, H.P., "Index of Auxiliary Substances", Pharm. Ind. 1989, 12, 1446-1449.
Friberg, S. and Mandell, "Phase Equilibria and Their Influence on the Properties of Emulsions", J. of the Am. Oil Chemists' Society 1970, 47, 149-152.
Ganguly, R. and Waldman, "Active and Passive Immunization", in Fundamentals of Immunology and Allergy, Lockey and Bukantz, ed., W.B. Saunders Company, Philadelphia, 1987, pp. 243-259.
Gulik-Krzywicki, T. and Larsson, "An Electron Microscopy Study of the L2-Phase (Microemulsion) in a Ternary System: Triglyceride/Monoglyceride/Water", Chemistry and Physics of Lipids 1984, 35, 127-132.
Kale, N. and Allen, "Studies on Microemulsions Using Brij 96 as Surfactant and Glycerin, Ethylene Glycol and Propylene Glycol as Cosurfactants", Int. J. of Pharmaceutics 1989, 57, 87-93.
Kemken, J. et al., "Influence of Supersaturation on the Pharmacodynamic Effect of Bupranolol After Dermal Administration Using Microemulsions as Vehicle", Pharmaceutical Research 1992, 9(4), 554-558.
"Kirk-Othmer Encyclopedia of Chemical Technology", 3rd Ed, vol. 8, pp.908, 913-918, 929, John Wiley & Sons, New York, 1979.
Larsson, K., "Emulsions of Reversed Micellar Phases and Aqueous Dispersions of Cubic Phases of Lipids", Am. Chem. Soc. 1991, 45-50.
Luisi, P.L. et al., "Reverse Micelles as Hosts for Proteins and Small Molecules", Biochim. Biophys. Acta 1988, 947, 209-246.
Muller, B.W. and Kleinebudde, "Investigations of So-Called Microemulsion Systems. Part 1: Investigations of Drug-Free Systems", Pharm. Ind. 1988, 50 (3), 370-375.
Muller, B.W. and Kleinebudde, "Investigations of So-Called Microemulsions. Part 2: Investigations of Drug-Containing Systems", Pharm. Ind. 1988, 50 (11), 1301-1306.
Overkamp, D. et al., "Production of Polyclonal Antibodies in Ascitic Fluid of Mice: Technique and Applications", J. of Immunoassay 1988, 9(1), 51-68.
Pilman, E. et al., "Inverse Micellar Phases in Ternary Systems of Polar Lipids/Fat/Water and Protein Emulsification of Such Phases to Water/Oil/Water-Microemulsion-Emulsions", J. Dispersion Science and Technology 1980, 1(3), 267-281.
Ritschel, W.A., "Microemulsion for Improved Peptide Absorption from the Gastrointestinal Tract", Meth. Fund. Exp. Clin. Pharmacol. 1991, pp. 205-220.
Rizzo, V., "Hydrophilic Molecules Solubilized in Water-in-Oil Microemulsions: Distribution of Species in a Chemical Equilibrium", J. of Colloid and Interface Science 1986, 110(1), 110-113.
Thompson, K. and Gierasch, "Conformation of a Peptide Solubilizate in a Reversed Micelle Water Pool", J. Am. Chem. Soc. 1984, 106, 3648-3652.
Pouton, C.W., "A Study of Self-Emulsifying Oil/Surfactant Mixtures", Dept. of Pharmacy, Chelsea College, University of London, Jan. 1982, pp. 1-252.
Wakerly, M.G., "Self-Emulsifying Drug Delivery Systems Based on Nonionic Surfactant-Oil Mixtures", University of Bath, 1989.
07/962,956 Oct. 16, 1992 Constantinides.
07/962,957 Oct. 16, 1992 Constantinides.
Owen Albert J.
Yiv Seang H.
LDS Technologies, Inc.
Russel Jeffrey E.
LandOfFree
Convertible microemulsion formulations does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Convertible microemulsion formulations, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Convertible microemulsion formulations will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2408848