Conversion of stereoisomer into its diastereoisomer

Details Conversion of stereoisomer into its diastereoisomer Conversion of stereoisomer into its diastereoisomer

1978-06-09

1980-07-22

Torrence, Dolph H.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424304, C07C12166, C07C12175

Patent

active

042139163

ABSTRACT:
A process for the conversion of a stereoisomer into its diastereoisomer of a compound having the following general formula: ##STR1## (wherein the asterisk denotes an asymmetric carbon atom; each X is individually hydrogen, alkyl, aryl, alkaryl, aralkyl, alkoxy, aryloxy, halogen, nitro, hydroxy or cyano; R is an organic residue containing one or more centers of asymmetry; and n is 1 to 5), which comprises subjecting the said stereoisomer to the action of an alkali metal carbonate and an inert polar solvent at a temperature in the range 20.degree. to 100.degree. C. and physically separating the required diastereoisomer from the resulting mixture of diastereoisomers.

REFERENCES:
patent: 4061644 (1977-12-01), Wood
patent: 4133826 (1979-01-01), Warnant et al.
Dale et al., J. Amer. Chem. Soc., 90:14, pp. 3732-3738 (1968).
Hauser et al., J. Amer. Chem. Soc., 95(13), pp. 4345-4348 (1958).
Howe et al., Chemical Abstracts, vol. 79, 52682z (1973).
Smejkal et al., Chemical Abstracts, vol. 59, 7396d (1963).
Weidmann et al., Chemical Abstracts, vol. 67, 21352q (1967).

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