Conversion of prostaglandin analogs into a bicarbonate insoluble

Details Conversion of prostaglandin analogs into a bicarbonate insoluble Conversion of prostaglandin analogs into a bicarbonate insoluble

1983-05-06

1987-05-05

Reamer, James H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

568379, C07C 4570

Patent

active

046634860

ABSTRACT:
A method for oligomerization of a group of prostaglandin analogs such as Ethyl Analog 3-(trans-3-keto-1-pentenyl)-2-ethyl-2-cyclopentenone into a biologically active exhibiting protection of oxidative phosphorylation of degenerated mitochondria and sodium bicarbonate insoluble oligomeric mixtures is described. The Ethyl Analog is treated with ethanolic potassium hydroxide solution in an oxygen-free atomsphere at moderate conditions of temperature, time and concentration.

REFERENCES:
patent: 4245111 (1981-01-01), Polis et al.
patent: 4338466 (1982-07-01), Nelson

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