Conversion of prostaglandin analogs into a bicarbonate insoluble

Details Conversion of prostaglandin analogs into a bicarbonate insoluble Conversion of prostaglandin analogs into a bicarbonate insoluble

1983-05-06

1987-05-26

Reamer, James H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

568379, C07C 4570

Patent

active

046688285

ABSTRACT:
A method for oligomerization of a group of prostaglandin analogs such as Ethyl Analog 3-(trans-3-keto-1-pentenyl)-2-ethyl-2-cyclopentenone into a biologically active exhibiting protection of oxidative phosphorylation of degenerated mitochondria and sodium bicarbonate soluble oligomeric mixtures is described. The Ethyl Analog is treated with ethanolic potassium hydroxide solution with exposure to atmospheric oxygen at moderate conditions of temperature, time and concentration.

REFERENCES:
patent: 4245111 (1981-01-01), Polis et al.
patent: 4338466 (1982-07-01), Nelson

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