Conversion of N-(4-fluorophenyl)-2-hydroxy-N-(1-methylethyl) ace

Details Conversion of N-(4-fluorophenyl)-2-hydroxy-N-(1-methylethyl) ace Conversion of N-(4-fluorophenyl)-2-hydroxy-N-(1-methylethyl) ace

1997-12-12

1998-09-15

Burn, Brian M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

564200, C07C23112

Patent

active

058081534

ABSTRACT:
The present invention provides a process for converting N-(4-fluorophenyl)-2-hydroxy-N-(1-methylethyl)acetamide acetate to N-(4-fluorophenyl)-2-hydroxy-N-(1-methylethyl)acetamide. The process includes the step of hydrolyzing N-(4-fluorophenyl)-2-hydroxy-N-(1-methylethyl)acetamide acetate with water or an aqueous alkali in the presence of an aprotic, aromatic solvent.

REFERENCES:
patent: 4334073 (1982-06-01), Diehr
patent: 5101034 (1992-03-01), Schmidt et al.

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