Conversion of aristeromycin into cyclaradine

Details Conversion of aristeromycin into cyclaradine Conversion of aristeromycin into cyclaradine

1986-05-20

1988-04-26

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544276, C07D47332, A61K 3152

Patent

active

047405988

ABSTRACT:
A process for the conversion of aristeromycin into cyclaradine via. The stereoselective reduction of a 3',5'-di-O-protected-2'-keto derivative of aristeromycin is disclosed.

REFERENCES:
patent: 4138562 (1979-02-01), Vince et al.
T. L. Nagabhushan et al., Abstracts of Papers presented at the 185th ACS National Meeting, Seattle, Washington 1983-CARB #27.
T. W. Greene, "Protective Groups in Organic Synthesis", Wiley-Interscience, N.Y., Chapter 2, pp. 10-86.
T. Kusaka et al., The Journal of Antibiotics, vol. XXI, pp. 255-263 (1968).
H. C. Brown et al., J. Am. Chem. Soc., vol. 92 (1970), pp. 709-710.
H. O. House, Modern Synthetic Reactions, 2nd Ed W. A. Benjamin, Inc. N.Y., 1972, pp. 54-70.
E. J. Corey et al., J. Am. Chem. Soc., vol. 93 (1971), pp. 1491-1493 and 7319-7320.
F. Hansske et al., Tetrahedron, vol. 40, No. 1 (1984), pp. 125-135.

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