Conversion of apoptotic proteins

Details Conversion of apoptotic proteins Conversion of apoptotic proteins

2007-02-13

2007-02-13

Achutamurthy, Ponnathapu (Department: 1652)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

C435S007100, C530S350000

Reexamination Certificate

active

11245845

ABSTRACT:
Compounds that modulate the function of anti-apoptotic proteins such as Bcl-2 and Bcl-XLare identified. These compounds have the ability to convert the activity of Bcl-2-family member proteins from anti-apoptotic to pro-apoptotic. Methods for inducing apoptosis are described, together with methods for identifying molecules that induce apoptosis through interaction with Bcl-2-family members.

REFERENCES:
patent: 6498195 (2002-12-01), Rosen et al.
patent: 6994976 (2006-02-01), Tittle et al.
patent: 2002/0137667 (2002-09-01), Chuenkova et al.
Chang et al., Isolation and characterization of human TR3 receptor: a member of steroid receptor superfamily, 1989, Steroid Biochem., vol. 34, Nos. 1-16, pp. 391-395.
Bohm et al., “The 5'-untranslated region of p23 mRNA form the Ehrlich ascites tumor is involved in translation control of the growth related protein p23” 1991,Biomed Biochim Acta50:1193; 174:130.
Buolamwini, “Novel anticancer drug discovery” 1999,Curr Opin Chem Biol3:500-509.
Cheng et al., “Functional redundancy of Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis” 1997,EMBO J16:1865.
Cheng et al., “Conversion of Bcl-2 to a Bax-like Death Effector by Caspases” 1997,Science278:1966-1968.
Degterev et al., “Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-XL”2001,Nat Cell Biol3:173-182.
Del Bello et al., “Cleavage of Bcl-2 in oxidant- and cisplatin-induced apoptosis of human melanoma cells” 2001,Oncogene20:4591-4595.
Enyedy et al., “Discovery of Small-Molecule Inhibitors of Bcl-2 through Structure-Based Computer Screening” 2001,J Med Chem44:4313-4324.
Fadeel et al., “Cleavage of Bcl-2 is an early event in chemotherapy-induced apoptosis of human myloid leukemia cells” 1999,Leukemia13:719-728.
Finnegan et al., “Induction of apoptosis in prostate carcinoma cells by BH3 peptides which inhibit Bak/Bcl-2 interactions” 2001,Br J Cancer85:115-121.
Fujita et al., “Involvement of Bcl-2 Cleavage in the Acceleration of VP-16-Induced U937 Cell Apoptosis” 1998,Biochem Biophys Res Commun246:484-488.
Grandgirard et al., “Alphaviruses induce apoptosis in Bcl-2 overexpressing cells; evidence for a caspase-mediated, proteolytic inactivation of Bcl-2” 1998,EMBO J17:1268-1278.
Lewis et al., “Inhibition of virus-induced neuronal apoptosis by Bax” 1999,Nat Med5:832-835.
Li et al., “Molecular Determinants of AHPN (CD437)-Induced Growth Arrest and Apoptosis in Human Lung Cancer Cell Lines” 1998,Mol Cell Biol18:4719.
Li et al., “Cytochrome c Release and Apoptosis Induced by Mitochondrial Targeting of Nuclear Orphan Receptor TR3” 2000,Science289:1159.
Li et al. “Characterizatoin of Fortillin, a novel antiapoptotic protein” 2001,JBC276:47542-47549.
Liu et al., “Apoptotic signals delivered through the T-cell receptor of a T-cell hybrid require the Immediate-early gene nur77” 1994,Nature367:281.
Petros et al. “Rational for Bcl-XL/Bad peptide complex formation from structure, mutagenesis and biophysical studies” 2000,Protein Science9:2528-2534.
Reed, John C. “Bcl-2 Family Proteins: Regulators of Apoptosis and Chemoresistance in Hematologic Maliganancis”Sem Hematol1997, 34:9-19.
Tzung et al., “Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3” 2001,Nat Cell Biol3:183-191.
Uemura et al., “Antisense TR3 Orphan Receptor Can Increase Prostate Cancer Cell Viability with Etoposide Treatment” 1998,Endocrinology129:2329.
Weih et al., “Apoptosis of nur77/N10-Transgenic Thymocytes Involves the Fas/Fas Ligand Pathway”PNAS USA93:5533, May 28, 1996.
Woronicz et al., “Requirement for the Orphan steroid receptor Nur77 in apoptosis of T-cell hybridomas” 1994,Nature367:277.
Young et al., “Tumor-Promoting Phorbol Ester-Induced Cell Death and Gene Expression in a Human Prostate Denocarcinoma Cell Line”1994,Oncol.Res.6:203.

Affiliated with

Also associated with

Rating

Conversion of apoptotic proteins does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Conversion of apoptotic proteins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Conversion of apoptotic proteins will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3811835