Conversion of amides to isocyanates via phase transfer catalysis

Details Conversion of amides to isocyanates via phase transfer catalysis Conversion of amides to isocyanates via phase transfer catalysis

1980-01-16

1981-08-04

Torrence, Dolph H.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07C11804

Patent

active

042821673

ABSTRACT:
The present invention is a method of subjecting amides to a modified Hofmann reaction using a 2-phase aqueous/organic system. The Hofmann reaction is modified in the sense that the product is an organic isocyanate rather than an amine. Generally, the reaction employs a phase transfer catalyst although, for tertiary amides it has been discovered that use of the catalyst is not required.

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Wallis et al., Organic Reactions, John Wiley and Sons, Inc., New York, p. 267 (1949).
Morrison and Boyd, Organic Chemistry, Allyn and Bacon, Boston, 1960, p. 536.

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