Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2006-09-26
2006-09-26
Richter, Johann (Department: 1626)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
active
07112679
ABSTRACT:
The present invention relates to processes for the production of α-aryl-β-ketonitriles, which serve as synthetic intermediates in the preparation of a series of biologically important molecules such as corticotropin releasing factor (CRF) receptor antagonists.
REFERENCES:
patent: 3558318 (1971-01-01), Sheehan
patent: 4469688 (1984-09-01), D'Silva
patent: 4797492 (1989-01-01), Sumimoto et al.
patent: 6107508 (2000-08-01), Zhou et al.
patent: 6562965 (2003-05-01), Zhou et al.
patent: 2002/0053565 (2002-07-01), Nakai et al.
patent: 58-148858 (1983-09-01), None
Royer et al., Memoires Presentes A La Societe Chimique, “Recherches sur le benzofuranna. XI-Formation d'isoxazoles”, pp. 17746-1752 (1963).
Del Re Giuseppe, “Conjugation in unsaturated systems containing heteroatoms. I. The phenylisoxazoles”, Journal of the Chemical society, Absracts, pp. 3324-3330, (1962). Abstract provided.
Hiroyuki Yasuda, “Synthese of 4,5-disubstituted isoxazoles and their cleavage reaction with sodium ethoxide. II Application to the determination of attact point of ethyl formate on unsymmetrical ketones”, 79, pp. 623-627 (1959). Abstract provided.
Bowie et al., “Electron Impact Studies” Skeletal Rearrangement Fragments In The Mass Spectra Of Alkyl And Aryl Isoxazoles Australian J. Chem., 22, pp. 563-575 (1969).
Dominguez, E., et al., “A convenient one-pot preparative method for 4,5-diarylisoxazoles involving amine exchange reactions,”J. Org. Chem., 1966, 61, 5435-5439.
Ladadie, S., “3-aryl-2,4,-pentanediones from 3,5-dimethyl-4-iodoisoxazoles: an application of a palladium-catalyzed cross-coupling reaction,”Synthetic Communications, 1994, 24(5), 709-719.
Mitchell, R., et al., “N-bromosuccinimide-dimethylformamide: A mild selective nuclear monobromination reagent for reactive aromatic compounds,”J. Org. Chem., Jul. 2, 1979, 44, 4733-4735.
Olah, G., et al., “Iodination of deactivated aromatics with N-iodosuccinimide in trifluoromethanesulfonic acid via in situe generated superelectrophilic iodine trifluoromethanesulfonate,”J. Org. Chem., Jan. 5, 1993, 58, 3194-3195.
Rouiller, C.A., “Heterocyclic compounds—more than one hetero atom,”CA, 1962, 3465-3468.
Sakakibara, T., et al., “Halogenation of isoxazoles,”Chem. Express, 1989, 4, 85-88.
DeMunno, A., “On the base catalyzed ring opening of 3-unsubstituted isoxazoles. Derivatives of 4-and5-phenylisoxazole,”J. Chem. Soc., Perkin Trans., 1977, 9, 1121-1124.
Hiroyuki, Y., “Synthesis of 4,5-disubstitutes isoxazoles and their cleavage reaction with sodium ethoxide. II. Application to the determination of attack point of ethyl formate on unsymmetrical ketones,”Chemical Abstracts, Nov. 25, 1959, 53 and Zasshi, Y., 1959, 79, 623-627.
Larock, R.C., “Comprehensive organic transformations,” 1970, p. 57.
Ma Philip
Oh Lynette May
Zhou Jiacheng
Bristol--Myers Squibb Company
Makujina Shah R.
Richter Johann
Sackey Ebenezer
Woodcock & Washburn LLP
LandOfFree
Convergent synthesis of α-aryl-β-ketonitriles does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Convergent synthesis of α-aryl-β-ketonitriles, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Convergent synthesis of α-aryl-β-ketonitriles will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3612256