Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1997-10-21
2000-04-04
Seaman, D. Margaret
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C07D40100
Patent
active
060463333
ABSTRACT:
The present invention is directed to a novel convergent process for the preparation of the compound N-[1(R)-[(1,2-dihydro-1-methanesulfonyl-spiro[3H-indole-3,4'-piperdin]-1'- yl)carbonyl]-2-(phenylmethyl-oxy)ethyl]-2-amino-2-methyl-propanamide, and salts thereof, which has the structure: ##STR1## and which has the ability to stimulate the release of natural or endogenous growth hormone. This compound may be used to treat conditions which require the stimulation of growth hormone production or secretion such as in humans with a deficiency of natural growth hormone or in animals used for food or wool production where the stimulation of growth hormone will result in a larger, more productive animal.
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Ioannis Houpis, et al., Presentation at Gordon Res. Conf. New Hmpton, NH, Jul. 14, 1996, "Synthesis of the Orally Active Nonpeptidal Growth Hormone Secretagogue, MK-677".
A. A. Patchett, et al., Proc. Natl. Acad, Sci., USA, vol. 92, pp. 7001-7005, (1995), "Design and Biological Activities of L-163-191 (MK-067): A Potent, Orally Active Growth Hormone Secretagogue".
Dorziotis Ilias
Houpis Ioannis
Molina Audrey
Volante Ralph
Merck & Co. , Inc.
Rose David L.
Seaman D. Margaret
Thies J. Eric
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