Convenient stable non-hygroscopic crystalline solid forms of...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C549S035000, C549S039000

Reexamination Certificate

active

10710053

ABSTRACT:
A process for the manufacture of new crystalline salts of N-[2-(dimethylamino)ethyl]-1,2-dithiolane-3-pentanamide (racemic and chiral forms) is described. Such salts are stable, crystalline and have very good solubility in water. The salts exhibit antioxidant properties. They inhibit collagenase and elastase enzymes. They have excellent anti acne activity in addition tyrosinase inhibition. They are, by themselves and in combination with other known agents, important cosmetic ingredients.

REFERENCES:
patent: 6013663 (2000-01-01), Fujita et al.
patent: 6150358 (2000-11-01), Goldstein et al.
patent: 6204288 (2001-03-01), Pershadsingh et al.
patent: 6313164 (2001-11-01), Fujita et al.
patent: 7030154 (2006-04-01), Ames

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