Convenient method for the preparation of no-carrier-added...

Details Convenient method for the preparation of no-carrier-added... Convenient method for the preparation of no-carrier-added...

2006-11-07

2006-11-07

Saeed, Kamal A. (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

Reexamination Certificate

active

07132563

ABSTRACT:
This is a novel method for production of no-carrier-added O-(2-[18F]fluoroethyl)-L-Tyrosine, which has been proved a suitable PET (position emission tomography) probe for tumor diagnosis imaging, and the preparation of the title compound starts from precursors with the chemical structures as in Formula 1, wherein R1is a protective group for the carboxyl functional group, R2is a protective group for the amino group, and R3acts as a leaving group, R1represents an arylalkyl group, R2represents a carboxyl group, and R3represents a p-tosyloxy, methane sulfonyloxy or trifluoromethane sulfonyloxy or bromine, and the final purification of the product is using a separation column, which is very convenient for automated synthesis, and the invention uses the precursor with the chemical structures as in Formula 1.

REFERENCES:
patent: 6451835 (2002-09-01), Dekeyser
Hamacher, et al. Efficient routine production of the 18F-labelled amino acid O-(2-[18F]fluoroethyl)-L-tyrosine. Applied Radiation and Isotopes, 2002, 57, 853-856.

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