Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters
Reexamination Certificate
2006-11-21
2006-11-21
Saeed, Kamal A. (Department: 1626)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acid esters
Reexamination Certificate
active
07138540
ABSTRACT:
This is a new precursor and new method for the synthesis of no-carrier-added O-(2-[18F]fluoroethyl)-L-Tyrosine which has been proved a suitable PET (position emission tomography) probe for tumor diagnosis imaging, the preparation of the title compound starts from precursors with the chemical structures as in Formula 1, wherein R1is a protective group for the carboxyl functional group, R2is a protective group for the amino group, and R3acts as a leaving group. R1represents an arylalkyl group, R2represents a carboxyl group, and R3represents a p-tosyloxy, methane sulfonyloxy or trifluoromethane sulfonyloxy or bromine, the invention includes a method for the syntheses of new precursors with the chemical structures as in Formula 1.
REFERENCES:
patent: 6451835 (2002-09-01), Dekeyser
Hamacher, et al. Efficient routine production oc the 18F-labelled amino acid O-(2-[18F]fluoroethyl)-L-tyrosine. Applied Radiation and Isotopes, 2002, 57, 853-856.
Chen Jenn Tzong
Lee Ming Hsin
Lin Wuu Jyh
Lo Ai Ren
Wang Hsin Er
David Pai Chao-Chang
Institute of Nuclear Energy Research
Pai Patent & Trademark Law Firm
Saeed Kamal A.
Young Shawquia
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