Convenient method for large-scale isolation of hibiscus acid

Details Convenient method for large-scale isolation of hibiscus acid Convenient method for large-scale isolation of hibiscus acid

1999-07-30

2000-10-03

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549295, C07D30512, C07D30702

Patent

active

061275530

ABSTRACT:
The invention relates to a process for the isolation of Hibiscus acid or (+)hydroxycitric acid lactone (2S,3R-dihydroxy-1,2,3-propanetricarboxylic acid lactone) from the leaves of Hibiscus furcatus, Hibiscus sabdariffa and Hibiscus cannabinus. Garcinia acid, one of the optical isomers of hydroxycitric acid is a potentially interesting molecule and found extensive application in the pharmacological as well as synthetic fronts.

REFERENCES:
patent: 4005086 (1977-01-01), Guthrie
patent: 4006166 (1977-02-01), Guthrie
Acta Chem. Scand. vol. 23, Per M. Boll et al, Jan. 1969.
Acta Chemica Scandinavica vol. 23 pp. 286-293,Per Boll et al, Naturally occuring Lactones and Lactames, Jun. 1969.
C. Martius et al.; Darstellung, physiologisches Verbaiten und Bedeutung der (+)-Oxycitronensaure und uhner Isonieren; Z.Physiol.Chem. 33, 1941, 269, pp. 33-40.
P.Boll, et al.; Naturally Occurring Lactones and Lactames; Aeta Chemn. Scand. 23 (1969) No. 1; pp. 286-293.
J. Herrmann; Method for Alkylating Lactones; JCS Chem.Comm. 1973; pp. 711-712.
Y.S. Lewis et al.; (-)-Hydroxycitric Acid--The Principal Acid in the Fruits of Garcini Cambogia Desr.; Phytochemistry, 1965, vol. 4; pp. 619-625.
S.Drioli et al.; Synthesis of (+)- and (-)-Phaseolinic Acid by Combination of Enzymatic Hydrolysis and Chemical Transformations with Revision of the Absolute Configuration of the Natural Product; J. Org. Chem. 1998, pp. 2385-2388.
E. Moret et al.; A Diastereoselective Synthesis of Both Quercus Lactone Isomers Employing Allyl-type Organometallics as Key Intermediates; Tetrahedron Letters vol. 25, No. 40; 1984; pp. 4491-4494.
J.Triscari et al.; Comparative Effects of (-) hydrosycitrate and (+)-allo-hydroxy-citrate on Acetyl CoA Carboxylase and Fatty Acid and Cholesterol Synthesis in Vivo; Lipids 1977, 12(4), pp. 357-363.
H. Brunengraber et al; Effect of (-)-hydroxy citrate on Ketone Production by the Perfused Liver; Lab.Chim. M. Univ. Libra Brusceller, Brusceller, Brussels, Belg. FEBS Lett. 1976, 65 (2), pp. 251-253.

Affiliated with

Also associated with

Rating

Convenient method for large-scale isolation of hibiscus acid does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Convenient method for large-scale isolation of hibiscus acid, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Convenient method for large-scale isolation of hibiscus acid will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-197324