Chemistry: electrical and wave energy – Apparatus – Electrolytic
Patent
1992-01-15
1993-06-08
Niebling, John
Chemistry: electrical and wave energy
Apparatus
Electrolytic
204412, 204415, 204435, 435817, 435288, G01N 2726
Patent
active
052175944
ABSTRACT:
The invention relates to novel b of detecting metal ion concentrations less than about 10 .mu.g/dl fluid. Biosensors based on the enzyme isocitrate dehydrogenase are particularly suited for detecting trace lead ion concentrations in water and in blood. Bioelectrodes are fabricated from surface deposited colloidal gold adsorbed enzyme that retains high catalytic activity Other aspects of the invention include detection devices for convenient and rapid measurement of metal ions.
REFERENCES:
patent: 4581336 (1986-04-01), Malloy et al.
patent: 4820399 (1989-04-01), Senda et al.
patent: 4950378 (1990-08-01), Nagata
patent: 4970145 (1990-11-01), Bennett et al.
Crumbliss, A. L., Henkens, R. W., Kitchell, B. S., Perine, S. C., Stonehuerner, J., and Tubergen, K. R., "Amperometric Glucose Sensor Fabricated from Glucose Oxidase and a Mediator Co-Immobilized on a Colloidal Gold Hydrogel Electrode," Biosensors Technology: Fundamentals and Application, Chapter, 13, 1990, published in USA.
Crumbliss, A. L., Henkens, R. W., Hunter, K., Kitchell, B. S., O'Daley, J. P., Stonehuerner, J., and Tubergen, K. R., "The Influence of Colloidal Gold Surfaces on Enzyme Activity," ACS North Carolina Divisional Meeting, Sep. 1988, published in USA.
Crumbliss, A. L., Henkens, R. W., Kitchell, B. S., Perine, S. C., Stonehuerner, J., and Tubergen, K. R., "Amperometric Glucose Sensor Fabricated from Glucose Oxidase and a Mediator Co-Immobilized on a Colloidal Gold Hydrogel Electrode," ACS North Carolina Divisional Meeting, University of North Carolina at Chapel Hill, Sep. 7-9, 1989, published in USA.
Crumbliss, A. L., Kitchell, B. S., Perine, S. C., Stonehuerner, J., Tubergen, K. R., Zhao, J., and Henkens, R. W., "Catalytic and Electroactivity of Irreversibly Adsorbed Enzymes at Gold Electrode Surfaces," Symposium on Protein Electrochemistry: ACS Southeast Regional Meeting (SERM), Oct. 1989, published in USA.
Crumbliss, A. L., Henkens, R. W., Kitchell, B. S., McLachlan, K. L., O'Daly, J. P., Perine, S. C., Stonehuerner, J., Tubergen, K. R., and Zhao, J., "The Use of Inorganic Materials to Control or Maintain Immobilized Enzyme Activity," Symposium on opportunities for inorganic chemistry in biotechnology, ACS National Meeting in Boston, Apr. 23, 1990, published in USA.
Henkens, R. W., Kitchell, B. S., O'Daly, J. P., Perine, S. C., and Crumbliss, A. L., "Bioactive Electrodes Using Metallo Proteins Attached to Colloidal Gold," Recl.: Trav. Chim. Pays Bas, 106:298, 1987.
Henkens, R. W., Zhao, J., and O'Daly, J. P., "Multi-Analyte Enzyme Electrodes for Environmental Monitoring," Proceedings of 5th International Biotechnology Conference in Copenhagen, Jul. 8-13, 1990.
Albery et al., "Inhibited Enzyme Electrodes. Part 3.," Biosensors & Bioelectronics, 5:397-413, 1990, published in Great Britain.
Almestrand et al., "Determination of Lead in Whole Blood with a Simple Flow-Injection System and Computerized Stripping Potentiometry," Analytica Chimica Acta, 209:339-343, 1988, published in The Netherlands.
Baum & Czok, "Enzymatische Bestimmung vol ,, ionisiertem++ Magnesium in Plasma," Biochemische Zeitschrift, 332:121-130, 1959.
Botre et al., "Synthesis and Inhibitory Activity on Carbonic Anhydrase of Some New Sulpiride Analogues Studied by Means of a New Method," Journal of Medicinal Chemistry, 29:1814-1020, 1986.
"New Rules Set for Blood Lead Levels," Chemical and Engineering News, p. 17, Oct. 14, 1991.
Fair & Jamieson, "Studies of Protein Adsorption on Polystyrene Latex Surfaces," Journal of Colloid and Interface Science, 77(2):525-534, 1980.
Guilbault et al., "Homovanillic Acid as a Fluorometric Substrate for Oxidative Enzymes," Analytical Chemistry, 40(1):190-196, 1969.
Guilbault, "Determination of Inhibitors," Enzymatic Methods of Analysis, Pergamon Press, pp. 197-209, 1970, published in Great Britain.
Holleck, "The Reduction of Chlorine on Carbon in AlCl.sub.3 -KCl, NaCl Melts," Journal of the Electrochemical Society, 119(9):1158-1161.
"U.S. CDC Releases Revised Guidelines on Childhood Lead Poisoning-Blood Lead Level of Concern Lowered to .gtoreq.10 .mu.g/dl," ILZRO Environmental Update, 1(10):2, 1991.
Kamata & Onoyama, "Lead-Selective Membrane Electrode Using Methylene Bis(diisobutyldithiocarbamate) Neutral Carrier," Analytical Chemistry, 63:1295-1298, 1991.
Kratochvil et al., "Effect of Metals on the Activation and Inhibition of Isocitric Dehydrogenase," Analytical Chemistry, 39(1):45-51, 1967.
Linde, "Estimation of Small Amounts of Fluoride in Body Fluids," Analytical Chemistry, 31(12):2092-2094, 1959.
Morrissey & Han, "The Conformation of .gamma.-Gluobulin Adsorbed on Polystyrene Latices Determined by Quasielastic Light Scattering," Journal of Colloid and Interface Science, 65(3):423-431, 1978.
Sheikh & Townsend, "Aplications of Enzyme-Catalysed Reactions in Trace Analysis-VII," Talanta, 21:401-409, 1974, published in Great Britian.
Smit & Cass, "Cyanide Detection Using a Substrate-Regenerating, Peroxidase-Based Biosensor," Analytical Chemistry, 62:2429-2436, 1990.
Toren & Burger, "Trace Determination of Metal Ion Inhibitors of the Glucose-Glucose Oxidase System," Mikrochimica Acta (Wien), pp. 538-545, 1968.
Tran-Minh et al., "Studies on Acetylcholine Sensor and its Analytical Application Based on the Inhibition of Cholinesterase," Biosensors & Bioelectronics, 5:461-471, 1990.
Smith, "Air Pollution and Forest Damage," Chemical and Engineering News, pp. 30-42, Nov. 11, 1991.
Trade Brochure: esa, Inc. Trace Metal Analyzer Brochure, Bedford, Mass., A, 1990.
Gunasingham et al., "Performance and Evaluation of a Handheld Electrochemical Monitor for Toxic Metals," Cole-Parmer Instrument Company, Chciago, Illinois.
Henkens Robert W.
O'Daly John P.
Zhao Junguo
Bell Bruce F.
Enzyme Technology Research Group, Inc.
Niebling John
LandOfFree
Convenient determination of trace lead in whole blood and other does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Convenient determination of trace lead in whole blood and other , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Convenient determination of trace lead in whole blood and other will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1931472