Chemistry: electrical and wave energy – Processes and products – Processes of treating materials by wave energy
Patent
1993-06-07
1994-11-29
Niebling, John
Chemistry: electrical and wave energy
Processes and products
Processes of treating materials by wave energy
2041531, 204403, 436 74, 436 77, G01N 2726, G01N 3320
Patent
active
053687078
ABSTRACT:
The invention relates to methods of determining micromolar levels of lead ion in various fluids, including blood. Detection of lead or other heavy metal ion concentrations as low as 1 .mu.g/dL is achieved. The methods are adaptable to the detection of low levels of lead in whole blood, employing a novel separation and release of lead ion from lead chelating agents. The disclosed methods employ isocitrate dehydrogenase-based electrodes which are particularly suited for detecting nanomolar levels of lead.
REFERENCES:
patent: 4090926 (1978-05-01), Matson
patent: 4374041 (1983-02-01), Matson
patent: 4581336 (1986-04-01), Malloy et al.
patent: 4820399 (1989-04-01), Senda et al.
patent: 4950378 (1990-08-01), Nagata
patent: 4970145 (1990-11-01), Bennetto et al.
patent: 5160418 (1992-11-01), Mullen
patent: 5227307 (1993-07-01), Bar-Or et al.
patent: 5302531 (1994-04-01), Bauer
Albery et al., "Inhibited Enzyme Electrodes. Part 3., " Biosensors & Bioelectronics, 5:397-413, 1990, published in Great Britain.
Almestrand et al., "Determination of Lead in Whole Blood with a Simple Flow-Injection System and Computerized Stripping Potentiometry," Analytica Chimica Acta, 209:339-343, 1988, published in The Netherlands.
Baum & Czok, "Enzymatische Bestimmung von, ionisiertem Magnesium im Plasma," Biochemische Zeitschrift, 332:121-130, 1959.
Botre et al., "Synthesis and Inhibitory Activity on Carbonic Anhydrase of Some New Sulpiride Analogues Studied by Means of a New Method," Journal of Medicinal Chemistry, 29:1814-1020, 1986.
"New Rules Set for Blood Lead Levels," Chemical and Engineering News, p. 17, Oct. 14, 1991.
Fair & Jamieson, "Studies of Protein Adsorption On Polystyrene Latex Surfaces," Journal of Colloid and Interface Science, 77(2):525-534, 1980.
Guilbault et al., "Homovanillic Acid as a Fluorometric Substrate for Oxidative Enzymes," Analytical Chemistry, 40(1):190-196, 1968.
Guilbault, "Determination of Inhibitors," Enzymatic Methods of Analysis, Pergamon Press, pp. 197-209, 1970, published in Great Britain.
Holleck, "The Reduction of Chlorine on Carbon in AlCl.sub.3 -KCl, NaCl Melts," Journal of the Electrochemical Society, 119(9):1158-1161.
"U.S. CDC Releases Revised Guidelines on Childhood Lead Poisoning-Blood Lead Level of Concern Lowered to .gtoreq.10 .mu.g/dl," ILZRO Environmental Update, 1(10):2, 1991.
Kamata & Onoyama, "Lead-Selective Membrane Electrode Using Methylene Bis(diisobutyldithiocarbamate) Neutral Carrier," Analytical Chemistry, 63:1295-1298, 1991.
Kratochvil et al., "Effect of Metals on the Activation and Inhibition of Isocitric Dehydrogenase," Analytical Chemistry, 39(1):45-51, 1967.
Linde, "Estimation of Small Amounts of Fluoride in Body Fluids," Analytical Chemistry, 31(12):2092-2094, 1959.
Morrissey & Han, "The Conformation of .gamma.-Globulin Adsorbed on Polystyrene Latices Determined by Quasielastic Light Scattering," Journal of Colloid and Interface Science, 65(3):423-431, 1978.
Sheikh & Townshend, "Applications of Enzyme-Catalysed Reactions in Trace Analysis-VII," Talanta, 21:401-409, 1974 published in Great Britain.
Smit & Cass, "Cyanide Detection Using a Substrate-Regenerating, Peroxidase-Based Biosensor," Analytical Chemistry, 62:2429-2436, 1990.
Toren & Burger, "Trace Determination of Metal Ion Inhibitors of the Glucose-Glucose Oxidase System," Mikrochimica Acta (Wien), pp. 538-545, 1968.
Tran-Minh et al., "Studies on Acetylcholine Sensor and its Analytical Application Based on the Inhibition of Cholinesterase," Biosensors & Bioelectronics, 5:461-471, 1990.
Smith, "Air Pollution and Forest Damage," Chemical and Engineering News, pp. 30-42, Nov. 11, 1991.
Trade Brochure: esa, Inc. Trace Metal Analyzer Brochure, Bedford, Mass., 1990.
Gunasingham et al., "Performance and Evaluation of a Handheld Electrochemical Monitor for Toxic Metals," Cole-Parmer Instrument Company, Chicago, Ill.
Crumbliss, A. L., Henkens, R. W., Kitchell, B. S., Perine, S. C., Stonehuerner, J., and Tubergen, K. R., "Amperometric Glucose Sensor Fabricated from Glucose Oxidase and a Mediator Co-Immobilized on a Colloidal Gold Hydrogel Electrode," Biosensors Technology: Fundamentals and Application, Chapter 13, 1990, published in USA.
Crumbliss, A. L., Henkens, R. W., Hunter, K., Kitchell, B. S. O'Daly, J. P., Stonehuerner, J., and Tubergen, K. R., "The Influence of Colloidal Gold Surfaces on Enzyme Activity," ACS North Carolina Divisional Meeting, Sep. 1988, published in USA.
Crumbliss, A. L., Henkens, R. W., Kitchell, B. S., Perine, S. C., Stonehuerner, J., and Tubergen, K. R., "Amperometric Glucose Sensor Fabricated from Glucose Oxidase and a Mediator Co-Immobilized on a Colloidal Gold Hydrogel Electrode," ACS North Carolina Divisional Meeting, University of North Carolina at Chapel Hill, Sep. 7-9, 1989, published in USA.
Crumbliss, A. L., Kitchell, B. S., Perine, S. C., Stonehuerner, J., Tubergen, K. R., Zhao, J., and Henkens, R. W., "Catalytic and Electroactivity of Irreversibly Adsorbed Enzymes at Gold Electrode Surfaces," Symposium on Protein Electrochemistry: ACS Southeast Regional Meeting (SERM), Oct. 1989, published in USA.
Crumbliss, A. L., Henkens, R. W., Kitchell, B. S., McLachlan, K. L., O'Daly, J. P., Perine, S. C., Stonehuerner, J., Tubergen, K. R., and Zhao, J., "The Use of Inorganic Materials to Control or Maintain Immobilized Enzyme Activity," Symposium on opportunities for inorganic chemistry in biotechnology, ACS National Meeting in Boston, Apr. 23, 1990, published in USA.
Henkens, R. W., Kitchell, B. S., O'Daly, J. P., Perine, S. C., and Crumbliss, A. L., "Bioactive Electrodes Using Metallo Proteins Attached to Colloidal Gold," Recl.: Trav. Chim. Pays Bas, 106:298, 1987.
Henkens, R. W., Zhao, J., and O'Daly, J. P., "Multi-Analyte Enzyme Electrodes for Environmental Monitoring," Proceedings of 5th International Biotechnology Conference in Copenhagen, Jul. 8-13, 1990.
Sakai et al., "Determination of Heavy Metal Ions by Urea Sensor Using ISFET," Sensors and Materials, 2(4):217-227, 1991.
Sheikh, R. A., "The Determination of Nanogram Amounts of Indium, Lead and Drugs of Forensic Importance by Enzymic Inhibition," Proc. Soc. Analyt. Chem., 10(11):263-286, 1973.
PCT Search Report maield Apr. 5, 1993.
Henkens Robert W.
Liang Zhi-Wei
Morris Susan E.
O'Daly John P.
Wojciechowski Marek
Andcare, Inc.
Bell Bruce F.
Niebling John
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