Surgery – Means for introducing or removing material from body for... – Material introduced into and removed from body through...
Patent
1996-03-15
1998-02-24
Buiz, Michael Powell
Surgery
Means for introducing or removing material from body for...
Material introduced into and removed from body through...
604 21, A61M 3100
Patent
active
057207208
ABSTRACT:
A method of high-flow microinfusion which provides convection-enhanced delivery of agents into the brain and other solid tissue structures. The method involves positioning the tip of an infusion catheter within a tissue structure and supplying an agent through the catheter while maintaining a pressure gradient from the tip of the catheter during infusion. Agent delivery rates of 0.5 to 15.0 .mu.l/min have been used experimentally with infusion distances greater than 1 cm from the delivery source. The method can be used to delivery various drugs, protein toxins, antibodies for treatment or imaging, proteins in enzyme replacement therapy, growth factors in the treatment of various neurodegenerative disorders and viruses and gene therapy. An infusion catheter developed for the high-flow microinfusion includes a plurality of elongated slits adjacent a tapered portion of the catheter which are parallel to the axis of the catheter and spaced symmetrically about the circumference thereof. The infusion catheter is used in a convention-enhanced delivery system in which, after the infusion catheter is positioned in a tissue situs, it is connected to a pump which delivers a desired agent and maintains a desired pressure gradient throughout delivery of the agent.
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Bobo Richard Hunt
Dedrick Robert L.
Laske Douglas W.
Morrison Paul F.
Oldfield Edward H.
Buiz Michael Powell
Nguyen At
The United States of America as represented by the Department of
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