Conus californicus neurotoxins

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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C530S324000, C424S405000

Reexamination Certificate

active

07341998

ABSTRACT:
Novel conotoxin polypeptide and polynucleotide sequences are provided.

REFERENCES:
Whysner et al., “Purification of the lethal fraction of the venom of the marine snailConus californicus,” Toxicon 4(3):177-181, 1966.
Craig, A.G., et al., “An O-glycosylated neuroexcitatoryConusPeptide,” (1998)Biochemistry,37(46):16019-16025.
Duda, T.F., et al., “Evolutionary diversification of multigene families: allelic selection of toxins in predatory cone snails,” (2000)Mol. Biol. Evol.,17(9):1286-1293.
Duda, T.F., et al., “Gene expression and feeding ecology: evolution of piscivory in the venomous gastropod genusConus,” (2004)Proc. R. Soc. Lond.,271:1165-1174.
Gilly, W.F., et al., “All-or-none contraction and sodium channels in a subset of circular muscle fibers of squid mantle,” (1996)Biol. Bull.191:337-340.
Gilly, W.F., et al., “Control of the spatial distribution of sodium channels in giant fiber lobe neurons of the squid,” (1990)Neuron,5:663-674.
Gilly, W.F., et al., “Fast and slow activation kinetics of voltage-gated sodium channels in molluscan neurons,” (1997)J. Neurophysiol.,77:2373-2384.
Gilly, W.F., et al., “Properties of appropriately and inappropriately expressed sodium channels in squid giant axon and its somata,” (1989)The Journal of Neuroscience,9(4):1362-1374.
Jones, R.M., et al., “Conotoxins—new vistas for peptide therapeutics,” (2000)Current Pharmaceutical Design,6:1249-1285.
Mathes, C., et al., “Fast inactivation of delayed rectifier K conductance in squid giant axon and its cell bodies,” (1997)J. Gen. Physiol.,109:435-448.
McFarlane, M.B., et al., “Spatial localization of calcium channels in giant fiber lobe neurons of the squid (Loligo opalescens),” (1996)PNAS,93:5067-5071.
Schultz, J.R., et al., “The projectile tooth of a fish-hunting cone snail:Conus catusinjects venom into fish prey using a high-speed ballistic mechanism,” (2004)Biol. Bull.,207:77-79.
Wang, C-Z., et al., “Conuspeptides—a rich pharmaceutical treasure,” (2004)Acta Biochimica et Biophysica Sinica,36(11):713-723.
Bingham, J., et al., “A new highly selective conotixin fromConus californicusthat targets voltage-gated neuronal Na* channels of squid,” (2000)The Journal of General Physiology,116:12a-13a.
Hansson, K., et al., “Isolation and characterization of three novel Gla-containingConus marmoreusvenom peptides, one with a novel cysteine pattern,” (2004)Biochemical and Biophysical Research Communications,319:1081-1087.
Terlau, H., et al., “Conusvenoms: a rich source of novel ion channel-targeted peptides,”Physiology Review,84:41-68, 2004.
Whysner et al., “Purification of the Lethal Fraction of the Venom of the Marine SnailConus californicus,” Toxicon, 1966, vol. 4, pp. 177-181.
“International Search Report”, International Searching Authority, May 7, 2007, PCT/US06/18132, 5 pages.

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