Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2008-03-11
2008-03-11
Prouty, Rebecca S. (Department: 1652)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C530S324000, C424S405000
Reexamination Certificate
active
07341998
ABSTRACT:
Novel conotoxin polypeptide and polynucleotide sequences are provided.
REFERENCES:
Whysner et al., “Purification of the lethal fraction of the venom of the marine snailConus californicus,” Toxicon 4(3):177-181, 1966.
Craig, A.G., et al., “An O-glycosylated neuroexcitatoryConusPeptide,” (1998)Biochemistry,37(46):16019-16025.
Duda, T.F., et al., “Evolutionary diversification of multigene families: allelic selection of toxins in predatory cone snails,” (2000)Mol. Biol. Evol.,17(9):1286-1293.
Duda, T.F., et al., “Gene expression and feeding ecology: evolution of piscivory in the venomous gastropod genusConus,” (2004)Proc. R. Soc. Lond.,271:1165-1174.
Gilly, W.F., et al., “All-or-none contraction and sodium channels in a subset of circular muscle fibers of squid mantle,” (1996)Biol. Bull.191:337-340.
Gilly, W.F., et al., “Control of the spatial distribution of sodium channels in giant fiber lobe neurons of the squid,” (1990)Neuron,5:663-674.
Gilly, W.F., et al., “Fast and slow activation kinetics of voltage-gated sodium channels in molluscan neurons,” (1997)J. Neurophysiol.,77:2373-2384.
Gilly, W.F., et al., “Properties of appropriately and inappropriately expressed sodium channels in squid giant axon and its somata,” (1989)The Journal of Neuroscience,9(4):1362-1374.
Jones, R.M., et al., “Conotoxins—new vistas for peptide therapeutics,” (2000)Current Pharmaceutical Design,6:1249-1285.
Mathes, C., et al., “Fast inactivation of delayed rectifier K conductance in squid giant axon and its cell bodies,” (1997)J. Gen. Physiol.,109:435-448.
McFarlane, M.B., et al., “Spatial localization of calcium channels in giant fiber lobe neurons of the squid (Loligo opalescens),” (1996)PNAS,93:5067-5071.
Schultz, J.R., et al., “The projectile tooth of a fish-hunting cone snail:Conus catusinjects venom into fish prey using a high-speed ballistic mechanism,” (2004)Biol. Bull.,207:77-79.
Wang, C-Z., et al., “Conuspeptides—a rich pharmaceutical treasure,” (2004)Acta Biochimica et Biophysica Sinica,36(11):713-723.
Bingham, J., et al., “A new highly selective conotixin fromConus californicusthat targets voltage-gated neuronal Na* channels of squid,” (2000)The Journal of General Physiology,116:12a-13a.
Hansson, K., et al., “Isolation and characterization of three novel Gla-containingConus marmoreusvenom peptides, one with a novel cysteine pattern,” (2004)Biochemical and Biophysical Research Communications,319:1081-1087.
Terlau, H., et al., “Conusvenoms: a rich source of novel ion channel-targeted peptides,”Physiology Review,84:41-68, 2004.
Whysner et al., “Purification of the Lethal Fraction of the Venom of the Marine SnailConus californicus,” Toxicon, 1966, vol. 4, pp. 177-181.
“International Search Report”, International Searching Authority, May 7, 2007, PCT/US06/18132, 5 pages.
Gilly William F.
Neofitovic-Lebaric Zora
Bozicevic, Field & Francais LLP
Kosson Rosanne
Prouty Rebecca S.
Sherwood Pamela J.
The Board of Trustees of the Leland Stanford Junior University
LandOfFree
Conus californicus neurotoxins does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Conus californicus neurotoxins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Conus californicus neurotoxins will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2801913