Controlling osteogenesis by inhibition of osteogenic...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C536S023100, C536S024500, C435S325000

Reexamination Certificate

active

07601501

ABSTRACT:
The present invention provides methods of screening for agents that inhibit the activity or expression of one or more polypeptides that contribute to the suppression of osteogenesis. The invention also provides methods of inducing osteogenesis in a cell by administering to the cell an agent that inhibits one or more polypeptides that contribute to the suppression of osteogenesis.

REFERENCES:
patent: 2004/0157864 (2004-08-01), Wu et al.
patent: 2005/0176707 (2005-08-01), Chen et al.
patent: 2006/0019907 (2006-01-01), Aggarwal et al.
patent: 2007/0254884 (2007-11-01), Shuibing et al.
patent: WO 94/06438 (1994-03-01), None
Wei et al., International Union of Pharmacology. LII. Nomenclature and Molecular Relationships of Calcium-Activated Potassium Channels, 2005, Pharmacol Rev, vol. 57, No. 4, pp. 463-472.
Campagnoli, C. et al., “Identification of mesenchymal stem/progenitor cells in human first-trimester fetal blood, liver, and bone barrow,” 2001, Blood, 98:2396-2402.
Caplen, N. J. et al., “Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems,” Proc Natl Acad Sci U S A, 98:9742-9747 (2001).
Dezawa, M. et al., “Specific induction of neuronal cells from bone marrow stromal cells and application for autologous transplantation,” 2004, J Clin Invest., 113:1701-1710.
Dezawa, M. et al., “Bone Marrow Stromal Cells Generate Muscle Cells and Repair Muscle Degeneratio,” 2005, Science, 309:314-317.
Horwitz, E. M. et al., “Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: Implications for cell therapy of bone,” 2002, Proc Natl Acad Sci U S A, 99:8932-8737().
Paddison, P. J. et al., “Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells,” Genes Dev 16:948-958 (2002).
Paddison, P. J. et al., “A resource for large-scale RNA-interference-based screens in mammals,” Nature 428:427-431 (2004).
Patil, et al., “DNA-Based Therapeutics and DNA Delivery Systems: a Comprehensive Review,” 2005, AAPS Journal, 7(1), 9, E61-E77.
Pittenger, et al., “Multilineage Potential of Adult Human Mesenchymal Stem Cells,” 1999, Science, vol. 284, 143-147.
Pittenger, M. F. et al., “Mesenchymal Stem Cells and Their Potential as Cardiac Therapeutics,” Circ Res 95:9-20 (2004).
Prockop, D. J. “Adult stem cells gradually come of age,” Nat Biotechnol 20:791-792 (2002).
Prockop, D. J. “Marrow Stromal Cells as Stem Cells for Nonhematopoietic Tissues,” Science 276:71-74 (1997).
Ryan, J. M. et al., “Mesenchymal stem cells avoid allogeneic rejection,” J Inflamm (Lond) 2:8 (2005).
Sui, G. et al., “A DNA vector-based RNAi technology to suppress gene expression in mammalian cells,” Proc Natl Acad Sci U S A 99:5515-5520 (2002).
Woodbury, D. et al., “Adult rat and human bone marrow stromal cells differentiate into neurons,” J Neurosci Res 61:364-370 (2000).
Yu, J. Y. et al., “RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells,” Proc Natl Sci U S A 99:6047-6052 (2002).
Zheng, L. et al., “An approach to genomewide screens of expressed small interfering RNAs in mammalian cells,” Proc Natl Acad Sci U S A 101:135-140 (2004).
Bertaux, Karine et al.; “Runx2 regulates the expression of GNAS of SaOs-2 cells”; 2006,Bone, vol. 38, pp. 943-950.
Riminucci, M. et al.; “Osteoclastogenesis in fibrous dysplasia of bone: in situ and in vitro analysis of IL-6 expression”; 2003,Bone, vol. 33, pp. 434-442.
Zamurovic, Natasa et al.; “Coordinated Activation of Notch, Wnt, and Transforming Growth Factor-β Signaling Pathways in Bone Morphogenic Protein 2-induced Osteogenesis”; 2004,The Journal of Biological Chemistry, vol. 279, No. 36, pp. 37704-37715.
Zhao, et al., “A High Throughput siRNA Library Screen Identifies Osteogenic Suppressors in Human Mesenchymal Stem Cells,” PNAS, Jun. 5, 2007, vol. 104, No. 23, pp. 9673-9678.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Controlling osteogenesis by inhibition of osteogenic... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Controlling osteogenesis by inhibition of osteogenic..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Controlling osteogenesis by inhibition of osteogenic... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4107416

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.