Controlling nitrogen oxide concentrations to modulate skeletal m

Details Controlling nitrogen oxide concentrations to modulate skeletal m Controlling nitrogen oxide concentrations to modulate skeletal m

1994-12-05

1996-08-13

Russel, Jeffrey E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514185, 5142248, 514249, 514255, 514551, 514564, A61K 3842, A61K 31195, A61K 3122, A61K 31495

Patent

active

055456146

ABSTRACT:
A method for inhibiting or relaxing skeletal muscle contractions and for treating disease states resulting from or exacerbated by undesirable skeletal muscle contractions by administering a skeletal muscle relaxing amount of nitroxyl ion(NO.sup.-), nitrosonium ion(NO.sup.+), nitric oxide and nitric oxide adducts or providers. A process for stimulating, improving or enhancing muscle contraction in a mammal by treating the mammal with an effective amount of (i) a nitric oxide synthase inhibitor or (ii) a nitric oxide scavenger.

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J. Pharmacology and Experimental Therapeutics, vol. 254, No. 3, issued 1990, Wolin et al, "Methylene Blue Inhibits Vasodilation . . . ", pp. 872-876.
Pediatric Research, vol. 35 (4 Part 2), issued Apr. 1994, Williams et al, "Induction And Characterization of Inducible . . . ", p. 61A, abstract No. 350.

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