Controlled, sustained release delivery system for smoking cessat

Details Controlled, sustained release delivery system for smoking cessat Controlled, sustained release delivery system for smoking cessat

1993-10-13

1995-04-04

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424423, 424425, 424426, 424449, 424451, 424489, 424502, 514810, 514811, 514812, 514813, 514963, 514965, A61K 950, A61K 970, A61K 948

Patent

active

054035953

ABSTRACT:
A drug delivery system useful in aiding individuals in the cessation of smoking or chewing nicotine containing products is described. The delivery system includes a physical constraint modulation system (PCMS.TM.) containing lobeline. The drug delivery system is capable of delivering lobeline to an individual in a controlled, sustained release manner and providing long-term therapeutic levels of lobeline to the individual. The delivery of lobeline in such a manner reduces or eliminates the individual's smoking or chewing habit. The PCMS may be a biodegradable polymer containing the lobeline capable of subcutaneous or intramuscular injection or implantation into the individual or may be part of a transdermal patch containing lobeline. Also described are methods of using the drug delivery systems and kits containing the drug delivery systems.

REFERENCES:
patent: 3862946 (1975-01-01), Havera
patent: 3879555 (1975-04-01), Pachter et al.
patent: 3885027 (1975-05-01), Shaw et al.
patent: 3887699 (1975-06-01), Yolles
patent: 3906100 (1975-09-01), Havera
patent: 3947592 (1976-03-01), Grosz
patent: 3966940 (1976-06-01), Pachter
patent: 3976071 (1976-08-01), Sadek
patent: 3980766 (1976-09-01), Shaw et al.
patent: 4144228 (1979-03-01), Jones et al.
patent: 4145435 (1979-03-01), Szmuszkovicz
patent: 4177056 (1979-12-01), Mueller
patent: 4192827 (1980-03-01), Mueller
patent: 4248855 (1981-02-01), Blank et al.
patent: 4277582 (1981-07-01), Mueller et al.
patent: 4304591 (1981-12-01), Mueller et al.
patent: 4344431 (1982-08-01), Yolles
patent: 4361553 (1982-11-01), Loh et al.
patent: 4380550 (1983-04-01), Kleinlogel et al.
patent: 4444758 (1984-04-01), Scherschlicht et al.
patent: 4464378 (1984-08-01), Hussain
patent: 4592753 (1986-06-01), Panoz
patent: 4620977 (1986-11-01), Strahilevitz
patent: 4624665 (1986-11-01), Nuwayser
patent: 4632935 (1986-12-01), Kaplan
patent: 4698342 (1987-10-01), Crosby
patent: 4719215 (1988-01-01), Goldberg
patent: 4745160 (1988-05-01), Churchill et al.
patent: 4749576 (1988-06-01), Lee
patent: 4767628 (1988-08-01), Hutchinson
patent: 4789726 (1988-12-01), Hutchinson
patent: 4822617 (1989-04-01), Panoz
patent: 4834973 (1989-05-01), Strahilevitz
patent: 4873086 (1989-10-01), Good et al.
patent: 4898734 (1990-02-01), Mathiowitz et al.
patent: 4908213 (1990-03-01), Govil et al.
patent: 4920989 (1990-05-01), Rose et al.
patent: 4927676 (1990-04-01), Heiber et al.
patent: 4935428 (1990-06-01), Lewis
patent: 4943435 (1990-07-01), Baker et al.
patent: 4956391 (1990-09-01), Sapse
patent: 4963367 (1990-10-01), Ecanow
patent: 4994260 (1991-02-01), Kallstrand et al.
patent: 4996047 (1991-02-01), Kelleher et al.
patent: 5030216 (1991-07-01), Theeuwes et al.
patent: 5055478 (1991-10-01), Cooper et al.
Dorsey, J., "Control of the Tobacco Habit", Ann. Int. Medicine 10: 628-631 (1936).
Hoffstaedt, E., "The Use of Lobeline in the Treatment of Smokers" The Medical Journal of Australia (Feb. 24, 1964).
Kalyuzhnyy, V. V., [English Translation of Russian Original], J. of Neural Psychiat. 68: 1864-1870 (1968).
London, S. J., "Clinical Evaluation of a New Lobeline Smoking Deterrent", Current Therapeutic Res. 5: 167-175 (1963).
Perlstein, I. B., Symposium on Recent Advances in the Mecical Aspects of Smoking, The Matthew Publish. Co., N.Y. 40-45 (1964).
Prignot, J., "Pharmacological Approach to Smoking Cessation", Eur. Respir. J. 2: 550-560 (1969).
Swartz, H., "Clinical Evaluation of SMOKURB . . . ", Current Therapeutic Research 6: 290-296 (1964).
Scott, G. W. et al., "Buffered Lobeline as a Smoking Deterrrent", Lancet, 58-59, Jan. 6, 1962.
Davison, G. et al., "Lobeline and Reduction of Cigarette Smoking" Psychological Reports 31: 443-446 (1972).
Merry, J. et al., "The Effect of Buffered Lobeline . . . ", Practitioner 190: 628-631 (1963).
Rapp, G. W. et al., "A Critical Evaluation of a Lobeline Based Smoking Deterrent", Amer. J. Med. Sci. 230: 9-14 (1955).
Rapp, G. W. et al., "Absorption and Utility of Lobeline As A Smoking Deterrent", Amer. J. Med. Sci. 237: 287-292 (1959).
Wright, I. et al., "Lobeline Sulfate: Its Pharmacology and Use . . . " J. Amer. Med. Assn.: 109, 649-654 (1937).
Schuster, C. R. et al., Chapter 8: "The Effects of d-Amphetamine, Meprobate, and Lobeline on the Cigarette Smoking Behavior" (1979).
Mullenix, P. et al., "The Effects of Nicotine and Lobeline on Spontaneous Behavior of Adult Male Rats", (Forsyth Research Institute, Boston, Mass., sponsored by DynaGen, Inc., Cambridge, Mass. (1990).
Reavill, C., et al., "High Affinity Binding of [3H] (-)-Nicotine to Rat Brain Membranes . . . ", Neuropharmacology 27: 235-241 (1988).
Sloan, J. W., et al., "The Comparative Binding Characteristics of Nicotinic Ligands . . . ", Pharmacol. Biochem. Behav. 30(1): 255-267 (1988).
Takagi et al., "Lobeline-containing Skin Patch to discourage tobacco smoking", 63-6 Pharmaceuticals, 1989 (Abstract).
Derwent File Supplier WPI(L), AN=89-273364 [38], Derwent Publications Ltd, London, GB, & JPA,1197435 (Teikoku Seiyaku K.K.) Sep. 9, 1989.
Deasy, P. B., "Microencapuslation and related druf processes," Marcel Dekker, Inc., New York, pp. 223-224, Chapter 10.1.2: Narcotic antagonists (1984).

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