Controlled surface-associated delivery of genes and...

Details Controlled surface-associated delivery of genes and... Controlled surface-associated delivery of genes and...

2006-04-18

2006-04-18

Ketter, James (Department: 1636)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

C435S458000, C435S320100, C536S023100

Reexamination Certificate

active

07029697

ABSTRACT:
A system and methods for controlled gene delivery comprising condensed nucleic acids complexed with polylinkers, wherein the complexes are covalently and/or non-covalently bound to the surface of a substrate capable of supporting cell adhesion. The gene delivery system achieves temporal and spatial control of nucleic acid delivery to a target cell or cells through control of complex density on the surface of the support substrate, and reversibility of the attachment of the polylinker to the support substrate. The system and method of the invention can be used to create spatial patterns of gene expression, and in tissue engineering, high throughput screening, and gene therapy applications.

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