Controlled sensitivity immunochromatographic assay

Details Controlled sensitivity immunochromatographic assay Controlled sensitivity immunochromatographic assay

1994-08-08

1996-05-28

Spiegel, Carol A.

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

Carrier is particulate and the particles are of...

435 71, 435962, 435967, 435970, 436518, 436514, 436525, 436533, 436 66, 436810, 436824, 436825, 422 56, 422 58, 422 60, 422 61, 422101, G01N 33543

Patent

active

055211020

ABSTRACT:
An improved one-step immunochromatographic assay which involves the binding of a predetermined amount of analyte to an antibody, enabling the control of the assay sensitivity, is disclosed. The system is especially useful as a controlled sensitivity fecal occult blood assay. Antibodies to a desired analyte, present at a predetermined concentration, are deposited on the sample pad of the reaction unit. The antibody binds analyte present in the sample, up to a threshold amount. Analyte which is present in the sample at a level above the threshold amount proceeds unbound through the sample pad and onto a membrane, where it reacts with an antibody-coated latex and a second, immobilized antibody to generate a positive signal.

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