Controlled removal of human stratum corneum by pulsed laser to e

Details Controlled removal of human stratum corneum by pulsed laser to e Controlled removal of human stratum corneum by pulsed laser to e

1986-04-10

1988-10-04

Cohen, Lee S.

Surgery

Means for introducing or removing material from body for...

Infrared, visible light, ultraviolet, x-ray or electrical...

1283031, 128632, A61M 3700, A61B 1736

Patent

active

047753617

ABSTRACT:
A method of administering a therapeutic substance to a human patient, the method having the steps of ablating the stratum corneum of a region of the skin of the patient using pulsed laser light of wavelength, pulse length, pulse energy, pulse number, and pulse repetition rate sufficient to ablate the stratum corneum without significantly damaging the underlying epidermis, and applying the therapeutic substance to the region of ablation.

REFERENCES:
Guy et al. (1982) Clin. Res. 30 (1): 157A.
Guy et al. (1983) J. Pharm. Sci. 72 (9): 1077.
Lane et al. (1984) IBM Research Report--"Ultraviolet-Laser Ablation of Skin".
Jacques et al. (1985) Clin. Res. 33 (2): 299A.
Wolbarsht, "Laser Surgery: CO.sub.2 or HF" IEEE J Quantum Electronics, vol. QE 20, No. 12, Dec. 1984, pp. 1427-1432.

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