Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1994-02-23
1996-01-09
Russel, Jeffrey E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
424499, 424502, 514 2, A61K 916, A61K 3827
Patent
active
054829275
ABSTRACT:
An improved surface erodible controlled release composition and the manufacturing thereof, for the continuous administration of biologically active proteins or peptide fragments, is described. The biologically active protein is dissolved in water or a suitable solvent, alone or in combination with stabilizing agents. The solution is either lyophilized or spray dried to obtain a free flowing powder. The powder is then sieved to obtain the desired average particle size. The free flowing powder of the protein or the stabilized protein is then incorporated into a biodegradable matrix formed of fatty acid anhydride, fatty acid and/or a salt thereof. Examples using growth hormone and bovine serum albumin demonstrate enhanced release, stability and controlled release properties for the fatty acid anhydride microparticular system.
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patent: 4963368 (1990-10-01), Antrim et al.
patent: 5110595 (1992-05-01), Wang
Wang, "Lipids as Excipient in Sustained Release Insulin Implants," International Journal of Pharmaceutics, 54, 223 (1989).
Domb Abraham J.
Maniar Manoj
Massachusetts Institute of Technology
Russel Jeffrey E.
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