Controlled released microparticulate delivery system for protein

Details Controlled released microparticulate delivery system for protein Controlled released microparticulate delivery system for protein

1994-02-23

1996-01-09

Russel, Jeffrey E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

424499, 424502, 514 2, A61K 916, A61K 3827

Patent

active

054829275

ABSTRACT:
An improved surface erodible controlled release composition and the manufacturing thereof, for the continuous administration of biologically active proteins or peptide fragments, is described. The biologically active protein is dissolved in water or a suitable solvent, alone or in combination with stabilizing agents. The solution is either lyophilized or spray dried to obtain a free flowing powder. The powder is then sieved to obtain the desired average particle size. The free flowing powder of the protein or the stabilized protein is then incorporated into a biodegradable matrix formed of fatty acid anhydride, fatty acid and/or a salt thereof. Examples using growth hormone and bovine serum albumin demonstrate enhanced release, stability and controlled release properties for the fatty acid anhydride microparticular system.

REFERENCES:
patent: 4816568 (1989-03-01), Hamilton, Jr. et al.
patent: 4925661 (1990-05-01), Huang
patent: 4963368 (1990-10-01), Antrim et al.
patent: 5110595 (1992-05-01), Wang
Wang, "Lipids as Excipient in Sustained Release Insulin Implants," International Journal of Pharmaceutics, 54, 223 (1989).

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