Controlled release vehicle

Details Controlled release vehicle Controlled release vehicle

1990-05-09

1991-09-17

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424473, A61K 916, A61K 924, A61K 950

Patent

active

050493957

ABSTRACT:
A new controlled release vehicle which acts by breakdown of the entrapping material upon hydration has been developed. The preferred release vehicle is made of a carboxylated cellulose, e.g., carboxymethylcellulose, which is treated with a cross-linking agent such as aluminum ions and, preferably, a hydrophobicity agent such as acetic acid. The vehicle is broken down by a release agent, e.g., cellulase, which may be coated on the vehicle together with a coating agent, e.g., hydroxypropylcellulose. The vehicle is dried, entrapping the molecular to be entrapped, e.g., an enzyme, and hydration activates the cellulase which breaks down the carboxymethylcellulose, releasing the entrapped molecular.

REFERENCES:
patent: 3969280 (1976-07-01), Sayce et al.
patent: 3986510 (1976-10-01), Higuchi et al.
patent: 4090013 (1978-05-01), Ganslaw et al.
patent: 4160063 (1979-07-01), Titus
patent: 4486335 (1984-12-01), Majewicz
patent: 4610678 (1986-09-01), Weisman et al.
patent: 4786415 (1988-11-01), Shibata et al.
patent: 4812486 (1989-03-01), Hosokawa et al.
patent: 4826880 (1989-05-01), Lesniak et al.
Kyoritsu Yuki Kogyo, Computerized Abstract.
Diacel Chem. Ind. KK, Computerized Abstract.
Borrmeiste et al., Computerized Abstract.

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