Controlled release therapeutic wound dressings

Details Controlled release therapeutic wound dressings Controlled release therapeutic wound dressings

2002-12-06

2010-06-08

Wax, Robert A (Department: 1615)

Surgery: splint, brace, or bandage

Bandage structure

Skin laceration or wound cover

C424S433000

Reexamination Certificate

active

07732655

ABSTRACT:
A wound dressing comprising: a therapeutic agent selected from the group consisting of antimicrobial substances, pain relieving substances, protease inhibitors, and mixtures thereof; and a barrier layer for initially separating the therapeutic agent from a wound fluid in use, wherein the barrier layer comprises a substrate for an enzyme selected from the group consisting of proteases, kallikrein and tissue-plasminogen activator. Preferably the substrate comprises a substrate for elastase or a collagenase. The barrier layer breaks down in infected or chronic wounds, thereby releasing the therapeutic substance selectively into such wounds.

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