Controlled release therapeutic system for liquid pharmaceutical

Details Controlled release therapeutic system for liquid pharmaceutical Controlled release therapeutic system for liquid pharmaceutical

1995-02-22

1996-04-23

Phelan, D. Gabrielle

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424493, 424494, 424495, 424498, A61K 916

Patent

active

055101194

ABSTRACT:
Disclosed is a controlled release pharmaceutical dosage form, including: (a) microgranules of a pharmaceutical and an excipient; (b) a plurality of polymeric lipidic and wax-like coatings applied to the microgranules, the coated microgranules having dimensions which allow suspension of the coated microgranules in a liquid administration vehicle; and (c) a liquid administration vehicle for the coated microgranules, the vehicle including an effective amount of the pharmaceutical in a form immediately available upon ingestion. A process for the preparation of the controlled release therapeutic system is also described.

REFERENCES:
patent: 2921883 (1960-01-01), Reese
patent: 4193985 (1980-03-01), Bechgaard
patent: 4572833 (1986-02-01), Pedersen
patent: 4728512 (1988-03-01), Mehta
patent: 4780312 (1988-10-01), Appelgren
patent: 4820521 (1989-04-01), Panoz
patent: 4828840 (1989-05-01), Sakamoto
patent: 4876094 (1989-10-01), Benton
patent: 4935247 (1990-06-01), Marttila
patent: 5133947 (1992-07-01), Paradissis
patent: 5178868 (1993-01-01), Malmquist-Granlund
W. P. O'Neill, Chapter 4, Controlled Release Technologies: Methods, Theory and Applications, Kydonieus (ed), CRC Press, Inc., Boca Raton, Florida (1980).

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