Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Tablets – lozenges – or pills
Patent
1995-04-12
1996-11-19
Kulkosky, Peter F.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Tablets, lozenges, or pills
A61K 924
Patent
active
055760228
ABSTRACT:
The present invention pertains to controlled release tacrine drug delivery systems comprising an immediate release composition and a sustained release composition wherein (1) the immediate release composition comprises in percentages by weight of the immediate release composition: (A) immediate release pellets comprising: (a) nonpareil seeds in an amount from about 25% to about 75%; (b) tacrine in an amount from about 10% to about 80%; and (c) a binding agent in an amount from about 1% to about 10%; and (B) a sealing layer over the immediate release pellets comprising: (a) a sealing agent in an amount up to about 6%, and (b) a first plasticizing agent in an amount up to about 5%; and (2) the sustained release composition comprises in percentages by weight of the sustained release composition; (A) the immediate release composition; and (B) a sustaining layer over the immediate release composition comprising; (a) a water-insoluble polymer in an amount from about 40% to about 90%; (b) a water-soluble polymer in an amount up to about 10%; and (c) a second plasticizing agent in an amount up to about 10%; wherein the sustaining layer and the immediate release composition are present in the sustained release composition in a ratio by weight from about 1:9 to about 4:6, respectively, and the immediate release composition and the sustained release composition are present in the drug delivery system in a ratio by weight from about 0.01:1 to about 1:1, respectively.
REFERENCES:
patent: 3247066 (1966-04-01), Milosovich, Jr. et al.
patent: 4173626 (1979-11-01), Dempski et al.
patent: 4250166 (1981-02-01), Maekawa et al.
patent: 4728512 (1988-03-01), Mehta et al.
patent: 4794001 (1988-12-01), Mehta et al.
patent: 4839364 (1989-06-01), Shutske et al.
patent: 4904476 (1990-02-01), Mehta et al.
patent: 5013741 (1991-05-01), Shutske et al.
patent: 5085865 (1992-02-01), Nayak et al.
patent: 5133974 (1992-07-01), Paradissis et al.
patent: 5229135 (1993-07-01), Philippon et al.
J. Skelly, G. Amidon, W. Barr et al, "In vitro and in vivo testing and correlation for Oral Controlled/ modified-release dosage forms". Pharmaceutical Research, vol. 7, No. 9 pp. 975-982 (1990).
A. R. Hunter, "Tetrahydroaminacrine in Anesthesia". Br. J. Anesth., 37:505-513 (1965).
T. Gordh, A. Wahlin, "Potentiation of the neuromuscular effect of succinylcholine by tetrahydroamineacridine". Acta Anaesthiol Scand., 5:51-55 (1961).
W. K. Summers, L. V. Majovski, G. M. Marsch, K. Tachiki, and A. Kling, "Oral tetrahydroaminoacridine in long term treatment of senile dementia". N. Engl. J. Med., 315:1241-1245 (1986).
P. Hartvig, H. Askmark, S. M. Aquilonius, L. Wiklund, and B. Lindstrom, "Clinical pharmacokinetics of intravenous and oral 9-amino-1,2,3,4-tetrahydroacridine, tacrine". Eur. J. Clin. Pharmacol., 38:259-263 (1990).
Boisvert Wayne
Muhammad Nouman A.
Weiss Jay
Yang S. Shirley
Atkins Michael J.
Kulkosky Peter F.
Warner & Lambert Company
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