Controlled release systems containing heparin and growth factors

Details Controlled release systems containing heparin and growth factors Controlled release systems containing heparin and growth factors

1988-06-14

1992-03-31

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424423, 424426, 424484, 424485, 424488, 530399, 530813, 530815, 530816, 536 51, A61F 1300, A61F 200, A61K 914

Patent

active

051006685

ABSTRACT:
A system for stabilizing fibroblast-derived growth factors, maintaining their bioactivity over a prolonged period of time and controllably releasing them for use is disclosed. The system uses growth factors bound to biocompatible substrates via heparin or heparin derived compounds to maintain the bioactivity of the growth factors. A growth factor bound to a heparin coated substrate can be used independently as a controlled release device, or can be incorporated into a reservoir or matrix type controlled release devices to further enhance the controlled release properties. The stabilized growth factors can be implanted into a patient, thereby providing a means for producing an in vivo controlled release of a growth factor to the patient.

REFERENCES:
patent: 3645852 (1972-02-01), Axen et al.
patent: 3647630 (1972-03-01), Franks
patent: 3730841 (1973-05-01), Salvatore et al.
patent: 3746621 (1973-07-01), Kondo et al.
patent: 4038140 (1977-07-01), Jaworek et al.
patent: 4070348 (1978-01-01), Kraemer
patent: 4137127 (1979-01-01), Stocker
patent: 4138292 (1979-02-01), Chibata et al.
patent: 4164560 (1979-08-01), Folkman et al.
patent: 4373023 (1983-02-01), Langer et al.
patent: 4407957 (1983-10-01), Lim
patent: 4464468 (1984-08-01), Avrameas et al.
patent: 4613665 (1986-09-01), Larm
patent: 4678671 (1987-07-01), Feijen et al.
patent: 4786501 (1988-11-01), Janski et al.
Murphy et al., Molecular Endocrinology, 2(7) (1988).
Zhou et al., J. of Chromatograpy, 476 (1989).
Walicke et al., Proc. Natl Acad. Sci. U.S.A., 83:3012-3016 (1986).
Folkman et al., Science, 235:442 (1987).
Sullivan et al., J. Tissue Culture Meth., 10(2):125 (1986).
Langer et al., Methods in Enzymology, 112:399 (1985).
Murray et al., Cancer Drug Delivery, 1(2):119 (1984).
Murray et al., In Vitro, 19(10):743 (1983).
Langer et al., Annal. N. Y. Acad. Sci., (reprint), 1.

Affiliated with

Also associated with

Rating

Controlled release systems containing heparin and growth factors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Controlled release systems containing heparin and growth factors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Controlled release systems containing heparin and growth factors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2257675