Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai
Patent
1995-06-07
1996-07-30
Nutter, Nathan M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Cyclopentanohydrophenanthrene ring system doai
514170, 514177, 514179, 514964, 514965, 523113, 424422, A61K 3156
Patent
active
055411720
ABSTRACT:
Methods of treatment and prevention of estrogen-related diseases, and of fertility control, include low dose (e.g. less than 50 nanomolar serum concentration) administration of certain anabolic steroids, progestins and other substantially non-masculinizing androgenic compounds. Sustained release formulations substantially free of organic solvent, and sustained release formulations for maintaining low serum levels of androgen are disclosed.
REFERENCES:
patent: 3773919 (1973-11-01), Boswell
patent: 4107071 (1978-08-01), Bayless
patent: 4166800 (1979-09-01), Fong
patent: 4659695 (1987-04-01), Labrie
patent: 4818542 (1989-04-01), Deluca
patent: 4826831 (1989-05-01), Plunkett
patent: 4987268 (1991-01-01), Rauleder
patent: 5043331 (1992-08-01), Hirvonen
Chem. Abstr. 97(4):28542e (Jul. 26, 1982)
Poulin, et al., Breast Cancer Research and Treatment 12:213-325 (1988).
Poulin, et al., Breast Cancer Research and Treatment 13:161-172 (1989).
Young, et al., Am. J. Obstet. Gynecol. 137(3):284-292 (1980).
Janne, et al., Phmaracological Reviews 36(2):35S-42S (1984).
Poulin, et al., Endocrinology 125(1):392-399 (1989).
The Merck Index No. 5677, p. 909; No. 5687, p. 910 (1989).
The Merck Index No. 7486, p. 1188 Pizotyline (1989).
Wink and Felts, Calcif. Tissue Res. 32:77-82 (1986).
Wise, et al., Biology and Medicine pp. 237-270 (1979).
Young et al., Am. J. Obstet. Gynecol. 137:284-292 (1980).
Adair, et al., Ann. Surg. 123:1023-1035 (1946).
Adair, et al., JAMA 140:1193-2000 (1949).
Adair, Surg. Gynecol. Obstet. 84:719-722 (1947).
Allegra et al., Cancer Res. 39:1447-1454 (1979).
Aloia et al., Arch. Int. Med. 143:1700-1704 (1983).
Anderson, et al., Contraception 13:375-394 (1976).
Baker (1987) Controlled release of biologically active agents.
Beck, et al., Adv. in Human Fert. & Reprod. Endo., pp. 175-199 (1983).
Blossey et al., Cancer 54:1208-1215 (1984).
Blumenschein, Semin. Oncol. 10:7-10 (1983).
Centola, Cancer Res. 45:6264-6267 (1985).
Colvard, et al., Proc. Natl. Acad. Sci. 86:854-857 (1989).
Deutsch et al., Int. J. Gynecol. Obstet. 25:217-222 (1987).
Ehrlich et al., Am. J. Obstet Gynecol. 158:796-807 (1988).
Eriksen et al., Science 241:84-86 (1988).
Finkelstein et al., Ann. Int. Med. 106:354-361 (1987).
Gresser, et al., Contraception 17:253-267 (1978).
Hall, Fertility Regulation, Today and Tomorrow pp. 119-141 (1987).
Haller and Glick, Semin. Oncol. 13:2-8 (1986).
Hamblen, South Med. J. 50:743-750 (1987).
Hollo and Feher, Acta. Med. Hung. 20:233-247 (1964).
Hollo et al., Acta Med. Hung. 27:155-160 (1970).
Hollo et al., Lancet 1:1357 (1976).
Hortobagi et al., Breast Cancer Res. Treatm. 5:321-326 (1985).
Horwitz, J. Steroid Biochem. 27:447-457 (1987).
Horwitz et al., Cancer Res. 38:2434-2439 (1978).
Janne and Bardin, Pharmacol. Rev. 36:35S-42S (1984).
Kitchell, et al., Methods in Enzymology 112:436-448 (1985).
Komm, et al., Science 241:81-84 (1988).
Kramer, Biometrics 12:307-310 (1956).
Labrie, et al., J. Steroid Biochem. 28(4):379-384 (1987).
Labrie et al., Fertil Steril. 28:1104-1112 (1977).
Labrie, et al., Mol. Cell Endocrinol. 68:169-179 (1990).
Larrea, et al., J. Steroid Biochem. 27:657-663 (1987).
Lea et al., Cancer Res. 49:7162-7167 (1989).
Lim (1984) Biomedical Application of Microencapsulation.
Lippman, Semin. Oncol. 10(Suppl. 4):11-19 (1983).
Lippman, et al., Cancer Res. 36:4610-4618 (1976).
MacLaughlin, et al., J. Steroid Biochem. 10:371-377.
Mattsson, Breast Cancer Res. Treatm. 3:231-235 (1983).
Muechler and Kohler, Gynecol. Invest. 8:104 (1988).
Nathanson, et al., Rec. Prog. Horm. Res. 1:261-291 (1947).
Need, Clin. Orthop. 225:273-278 (1987).
Nordin, et al., J. Clin. Endocr. Metab. 60:651-657 (1985).
Ojasso et al., J. Steroid Biochem. 27:255-269 (1987).
Perez-Palacios et al., J. Steroid Biochem. 15:125-130 (1981).
Perez-Palacois et al., J. Steroid Biochem. 19:1729-1735 (1983).
Podratz et al., Obstet. Gynecol. 66: 106-110, 1985.
Poulin, et al., Br. Cancer Res. Treatm. 17:197-210 (1990).
Poulin et al., Cancer Res. 46:4933-4937 (1986).
Preston, Obstet, Gynecol. 2: 152-157, 1965.
Pridjian et al., J. Steroid Biochem. 26: 313-319.
Rodbard & Lewald In: 2nd Karolinska Symposium, Geneva, 1970, pp. 79-103.
Said, et al., Contraception 37:1-20 (1988).
Silberberg, et al., Biochem. & Physiol. of Bone 2(2):401-484 (1971).
Sledge & McGuire, Cancer Res. 38: 61-75, 1984.
Tatman et al., Eur. J. Cancer Clin. Oncol. 25: 1619-1621, 1989.
Urist & Vincent, J. Clin. Orthop. 18:199-208 (1961).
Verhas et al., Calif. Tissue Res. 39:74-77 (1986).
Vilchis, et al., J. Steroid Biochem. 24:525-531 (1986).
Van Veelen et al., Cancer Chemother. Pharmacol. 15:167-170 (1985).
Labrie Fernand
Lepage Martin
Endorecherche Inc.
Nutter Nathan M.
LandOfFree
Controlled release systems and low dose androgens does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Controlled release systems and low dose androgens, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Controlled release systems and low dose androgens will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1658652